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Hepatocyte growth factor (HGF) or scatter factor (SF) is a paracrine cellular growth, motility and morphogenic factor. It is secreted by mesenchymal cells and targets and acts primarily upon epithelial cells and endothelial cells , but also acts on haemopoietic progenitor cells and T cells .
Growth factor is sometimes used interchangeably among scientists with the term cytokine. [3] Historically, cytokines were associated with hematopoietic (blood and lymph forming) cells and immune system cells (e.g., lymphocytes and tissue cells from spleen, thymus, and lymph nodes).
15200 Ensembl ENSG00000113070 ENSMUSG00000024486 UniProt Q99075 Q06186 RefSeq (mRNA) NM_001945 NM_010415 RefSeq (protein) NP_001936 NP_034545 Location (UCSC) Chr 5: 140.33 – 140.35 Mb Chr 18: 36.64 – 36.65 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse Heparin-binding EGF-like growth factor (HB-EGF) is a member of the EGF family of proteins that in humans is encoded by the HBEGF ...
Human hepatocyte growth factor (HGF) is an 80kD [1] pleiotropic protein that is endogenously produced by a variety of cell types from the mesenchymal cell lineage (such as cardiomyocytes and neurons). [4] It is produced and proteolytically cleaved to its active state in response to cellular injury or during apoptosis.
Hepatocyte growth factor receptor (HGF receptor) [5] [6] is a protein that in humans is encoded by the MET gene. The protein possesses tyrosine kinase activity. [ 7 ] The primary single chain precursor protein is post-translationally cleaved to produce the alpha and beta subunits, which are disulfide linked to form the mature receptor.
Some skin secretions are associated with body hair. Skin secretions originate from glands that in dermal layer of the epidermis. Sweat, a physiological aid to body temperature regulation, is secreted by eccrine glands. Sebaceous glands secrete the skin lubricant sebum. Sebum is secreted onto the hair shaft and it prevents the hair from splitting.
Skin aging is caused in part by TGF-β, which reduces the subcutaneous fat that gives skin a pleasant appearance and texture. TGF-β does this by blocking the conversion of dermal fibroblasts into fat cells ; with fewer fat cells underneath to provide support, the skin becomes saggy and wrinkled.
Hepatocyte growth factor, a paracrine cellular growth, motility and morphogenic factor; Hereditary gingival fibromatosis, a rare condition of gingival overgrowth; Human Growth Foundation, an American patients' organization; Mercury(IV) fluoride (HgF), HgF4, is the first mercury compound to be discovered with mercury in the oxidation state IV