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Filgrastim, sold under the brand name Neupogen among others, is a medication used to treat low neutrophil count. [21] Low neutrophil counts may occur with HIV/AIDS , following chemotherapy or radiation poisoning , or be of an unknown cause. [ 21 ]
The structure of filgrastim differs slightly from the structure of the natural glycoprotein. Most published studies have used filgrastim. [citation needed] Filgrastim was first marketed by Amgen with the brand name Neupogen. Several bio-generic versions are now also available in markets such as Europe and Australia.
Pegfilgrastim, sold under the brand name Neulasta among others, is a PEGylated form of the recombinant human granulocyte colony-stimulating factor (GCSF) analog filgrastim. [19] It serves to stimulate the production of white blood cells (neutrophils). [19] [21] Pegfilgrastim was developed by Amgen. [22]
12981 Ensembl ENSG00000164400 ENSMUSG00000018916 UniProt P04141 P01587 RefSeq (mRNA) NM_000758 NM_009969 RefSeq (protein) NP_000749 NP_034099 Location (UCSC) Chr 5: 132.07 – 132.08 Mb Chr 11: 54.14 – 54.14 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse Protein family Granulocyte-macrophage colony-stimulating factor three-dimensional structure of recombinant human granulocyte ...
Lipegfilgrastim is a filgrastim biosimilar. [1] In lipegfilgrastim, the filgrastim has been 'pegylated' (attached to polyethylene glycol). [1] This slows down the medicine's removal from the body and allows the medicine to be given less often. [1] Lipegfilgrastim was authorized for medical use in the European Union in July 2013. [1]
Likewise, Viagra shouldn’t be combined with antiretroviral drugs used to treat HIV/AIDS, as it can cause an increased concentration of sildenafil in the body. Breastfeeding women shouldn’t ...
A new pain relief drug, suzetrigine, is a prescription pill that’s taken every 12 hours after a larger starter dose. It will be sold under the brand name Journavx.
Filgrastim is typically dosed in the 10 microgram/kg level for 4–5 days during the harvesting of stem cells. The documented adverse effects of filgrastim include splenic rupture , acute respiratory distress syndrome , alveolar hemorrhage, and allergic reactions (usually experienced in first 30 minutes).
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