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Salicylic acid is an organic compound with the formula HOC 6 H 4 COOH. [3] A colorless (or white), bitter-tasting solid, it is a precursor to and a metabolite of acetylsalicylic acid (aspirin). [3] It is a plant hormone, [8] and has been listed by the EPA Toxic Substances Control Act (TSCA) Chemical Substance Inventory as an experimental ...
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The therapeutic effects of salicylic acids were first documented in 1763 by Edward Stone, with acetylsalicylic acid being synthesized by Felix Hoffmann, a chemist working under Bayer, in 1897. [4] Acetylsalicylic acid-derived salt compounds were first discovered in 1970, [5] and the synthesis of lysine acetylsalicylate was first documented in ...
[14]: 69–75 That year, Felix Hoffmann (or Arthur Eichengrün) of Bayer was the first to produce acetylsalicylic acid in a pure, stable form. [15] Salicylic acid had been extracted in 1838 from the herb meadowsweet, whose German name, Spirsäure, was the basis for naming the newly synthesized drug, which, by 1899, Bayer was selling globally.
The drug should be taken with acid food or drink (orange, apple or tomato juice). [9] PAS was once available in a combination formula with isoniazid called Pasinah [10] or Pycamisan 33. [11] 4-Aminosalicylic acid was approved for medical use in the United States in June 1994, and for medical use in the European Union in April 2014. [12] [1]
Sodium salicylate is a sodium salt of salicylic acid. It can be prepared from sodium phenolate and carbon dioxide under higher temperature and pressure. Historically, it has been synthesized by refluxing methyl salicylate ( wintergreen oil) with an excess of sodium hydroxide .
Methyl salicylate (oil of wintergreen or wintergreen oil) is an organic compound with the formula C 8 H 8 O 3.It is the methyl ester of salicylic acid.It is a colorless, viscous liquid with a sweet, fruity odor reminiscent of root beer (in which it is used as a flavoring), [4] but often associatively called "minty", as it is an ingredient in mint candies. [5]
The enzyme acetylsalicylate deacetylase (EC 3.1.1.55) catalyzes the reaction acetylsalicylate + H 2 O salicylate + acetate. This enzyme belongs to the family of hydrolases, specifically those acting on carboxylic ester bonds. The systematic name is acetylsalicylate O-acetylhydrolase.