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Tazarotene, sold under the brand name Tazorac, among others, is a third-generation prescription topical retinoid. [2] [3] It is primarily used for the treatment of plaque psoriasis and acne. [4] Tazarotene is also used as a therapeutic for photoaged and photodamaged skin. [4] It is a member of the acetylenic class of retinoids. [4]
Third generation retinoids have narrow biological roles due to their constrained structure, with adapalene mimicking the effects of isotretinoin, [12] bexarotene binding only the Retinoid X receptors, and tazarotene binding the Retinoic acid receptor beta and Retinoic acid receptor gamma forms. [13]
It combines 0.01% halobetasol propionate (a corticosteroid that reduces inflammation and suppresses the immune system) and 0.045% tazarotene (a retinoid that promotes normal skin cell turnover and has anti-inflammatory effects) in a lotion formulation.
Tazarotene (Tazorac®): Prevents skin cells from building up and reduces inflammation, though it can be irritating Using a moisturizer alongside a retinoid is usually recommended to avoid over ...
“Retinoids vary in strength, with prescription-strength retinoids being the strongest and fastest acting but causing more skin irritation than over-the-counter retinol products,” says Henry.
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These effects are mediated by specific nuclear receptor proteins that are members of the steroid and thyroid hormone receptor superfamily of transcriptional regulators. RARRES1, RARRES2, and RARRES3 are genes whose expression is upregulated by the synthetic retinoid tazarotene. RARRES3 is thought act as a tumor suppressor or growth regulator. [4]
RARRES1, RARRES2 (this gene), and RARRES3 are genes whose expression is upregulated by the synthetic retinoid tazarotene. RARRES2 is thought to act as a cell surface receptor. [7] Chemerin is a chemoattractant protein that acts as a ligand for the G protein-coupled receptor CMKLR1 (also known as ChemR23).
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109 S High St #100, Columbus, OH · Directions · (614) 224-4261