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Daratumumab, sold under the brand name Darzalex among others, is an anti-cancer monoclonal antibody medication. It binds to CD38 , [ 7 ] which is overexpressed in multiple myeloma cells. [ 8 ]
Therapeutic, diagnostic and preventive monoclonal antibodies are clones of a single parent cell. When used as drugs, the International Nonproprietary Names (INNs) end in -mab.
It was approved for use in the United States in May 2020. [2] [7] [8]Efficacy of daratumumab and hyaluronidase-fihji (monotherapy) was evaluated in the COLUMBA trial (NCT03277105), an open-label non-inferiority trial randomizing 263 participants to daratumumab and hyaluronidase-fihj and 259 to intravenous daratumumab (daratumumab IV). [2]
COPENHAGEN, Denmark; October 15, 2024 – Genmab A/S (Nasdaq: GMAB) announced today that worldwide net trade sales of DARZALEX ® (daratumumab), including sales of the subcutaneous (SC) product (daratumumab and hyaluronidase-fihj, sold under the tradename DARZALEX FASPRO ® in the U.S.), as reported by Johnson & Johnson were USD 3,016 million ...
Similarly with DKRd, with the D representing Darzalex (brand name for daratumumab), and K representing Kyprolis (brand name for carfilzomib). [86] Emerging practice is not to call such drugs " chemotherapy " because they are not the traditional non-specific intracellular poisons that operate in the classic "chemo" fashion of inhibiting mitosis ...
COPENHAGEN, Denmark; January 22, 2025 – Genmab A/S (Nasdaq: GMAB) announced today that worldwide net trade sales of DARZALEX (daratumumab), including sales of the subcutaneous (SC) product (daratumumab and hyaluronidase-fihj, sold under the tradename DARZALEX FASPRO ® in the U.S.), as reported by J&J were USD 11,670 million in 2024.
Litter-Robot 3 Connect vs 4: Size Both devices are similar in footprint size, with the Litter-Robot 3 Connect measuring 24.25’’ x 27’’ and the Litter-Robot 4 measuring 22’’ x 27’’.
Swimming off the coast of Mexico in the Gulf of California live the few remaining vaquitas on earth. This endangered cetacean is not only the smallest porpoise species, but the most rare. Where ...
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