Search results
Results from the WOW.Com Content Network
Lipinski's rule of five, also known as Pfizer's rule of five or simply the rule of five (RO5), is a rule of thumb to evaluate druglikeness or determine if a chemical compound with a certain pharmacological or biological activity has chemical properties and physical properties that would likely make it an orally active drug in humans.
A traditional method to evaluate druglikeness is to check compliance of Lipinski's rule of five, which covers the numbers of hydrophilic groups, molecular weight and hydrophobicity. Since the drug is transported in aqueous media like blood and intracellular fluid, it has to be sufficiently water-soluble in the absolute sense (i.e. must have a ...
Christopher A. Lipinski is a medicinal chemist who is working at Pfizer, Inc. [1] He is known for his "rule of five" , an algorithm that predicts drug compounds that are likely to have oral activity. [ 1 ]
Download as PDF; Printable version; In other projects Wikimedia Commons; Wikidata item; ... Lipinski's rule of five; Looney 11 rule; M. Markovnikov's rule; Moore's law;
A post shared by Tara Lipinski (@taralipinski) "I was just, you know, very lucky to have parents that really tried to make sure that I had a healthy outlook towards that, especially as a ...
Bill Lipinski (born 1937), Polish-American politician; Christopher A. Lipinski, originator of Lipinski's rule of five to evaluate druglikeness; Dan Lipinski (born 1966), Polish-American politician; Dariusz Lipiński (born 1955), Polish politician; Edward Lipiński (economist) (1888-1986), Polish economist; Jacek Lipiński (born 1966), Polish ...
There are no rigorous methods for determining the precise size of this space. The assumptions [3] used for estimating the number of potential pharmacologically active molecules, however, use the Lipinski rules, in particular the molecular weight limit of 500. The estimate also restricts the chemical elements used to be Carbon, Hydrogen, Oxygen ...
the first has somehow, in some way, been my best year yet. So, as I often say to participants in the workshop, “If a school teacher from Nebraska can do it, so can you!”