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  2. RNA interference - Wikipedia

    en.wikipedia.org/wiki/RNA_interference

    RNA interference (RNAi) is a biological process in which RNA molecules are involved in sequence-specific suppression of gene expression by double-stranded RNA, through translational or transcriptional repression.

  3. RNA silencing - Wikipedia

    en.wikipedia.org/wiki/RNA_silencing

    The toxicity of RNA silencing is still under review as there are conflicting reports. [63] [64] [65] Number of RNAi publications since 1998. RNA silencing is quickly developing, because of that, the ethical issues need to be discussed further. With the knowledge of general ethical principles, we must continuously perform risk-benefit analysis. [63]

  4. RNA-induced silencing complex - Wikipedia

    en.wikipedia.org/wiki/RNA-induced_silencing_complex

    The RLC consists of dicer, the transactivating response RNA-binding protein and Argonaute 2. Dicer is an RNase III endonuclease which generates the dsRNA fragments to be loaded that direct RNAi. TRBP is a protein with three double-stranded RNA-binding domains. Argonaute 2 is an RNase and is the catalytic centre of RISC.

  5. Small interfering RNA - Wikipedia

    en.wikipedia.org/wiki/Small_interfering_RNA

    Small interfering RNA (siRNA), sometimes known as short interfering RNA or silencing RNA, is a class of double-stranded non-coding RNA molecules, typically 20–24 base pairs in length, similar to microRNA (miRNA), and operating within the RNA interference (RNAi) pathway.

  6. Gene silencing - Wikipedia

    en.wikipedia.org/wiki/Gene_silencing

    In 1986–1990, multiple examples of "coat protein-mediated resistance" against plant viruses were published, before RNAi had been discovered. [40] In 1993, work with tobacco etch virus first demonstrated that host organisms can target specific virus or mRNA sequences for degradation, and that this activity is the mechanism behind some examples ...

  7. DNA-directed RNA interference - Wikipedia

    en.wikipedia.org/wiki/DNA-directed_RNA_interference

    DNA-directed RNA interference (ddRNAi) is a gene-silencing technique that utilizes DNA constructs to activate a cell's endogenous RNA interference (RNAi) pathways. DNA constructs are designed to express self-complementary double-stranded RNAs, typically short-hairpin RNAs (shRNA), that bring about the silencing of a target gene or genes once processed. [1]

  8. Translation (biology) - Wikipedia

    en.wikipedia.org/wiki/Translation_(biology)

    For example, research utilizing this method has revealed that genetic differences and their subsequent expression as mRNAs can also impact translation rate in an RNA-specific manner. [ 21 ] Expanding on this concept, a more recent development is single-cell ribosome profiling, a technique that allows us to study the translation process at the ...

  9. RNA - Wikipedia

    en.wikipedia.org/wiki/RNA

    Ribonucleic acid (RNA) is a polymeric molecule that is essential for most biological functions, either by performing the function itself (non-coding RNA) or by forming a template for the production of proteins (messenger RNA). RNA and deoxyribonucleic acid (DNA) are nucleic acids.