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DNA damage-inducible transcript 3, also known as C/EBP homologous protein (CHOP), is a pro-apoptotic transcription factor that is encoded by the DDIT3 gene. [5] [6] It is a member of the CCAAT/enhancer-binding protein (C/EBP) family of DNA-binding transcription factors. [6]
CHOP is the acronym for a chemotherapy regimen used in the treatment of non-Hodgkin lymphoma. CHOP consists of: CHOP consists of: C yclophosphamide , an alkylating agent which damages DNA by binding to it and causing the formation of cross-links
Pulmonary toxicity, or lung damage, can occur with the use of bleomycin in ABVD, especially when radiation therapy to the chest is also given as part of the treatment for Hodgkin lymphoma. This toxicity develops months to years after completing chemotherapy, and usually manifests as cough and shortness of breath .
Children's Hospital was relocated to 22nd Street between Locust and Walnut Sts after the American Civil War.This hospital consisted of 35 beds and a dispensary.The second hospital was the site of the first surgery at CHOP, which was first performed in 1870.
Chronic obstructive pulmonary disease (COPD) is a type of progressive lung disease characterized by chronic respiratory symptoms and airflow limitation. [8] GOLD 2024 defined COPD as a heterogeneous lung condition characterized by chronic respiratory symptoms (dyspnea or shortness of breath, cough, sputum production or exacerbations) due to abnormalities of the airways (bronchitis ...
Chop, Ukraine, a city . Chop railway station; Meat chop, a cut of meat usually containing a rib and served as an individual portion; Seal (East Asia), or "chop" colloquially, used in East Asia to prove identity
The Children's Hospital of Philadelphia (CHOP) is also located on this campus. Although it engages in many collaborative efforts with Penn Medicine, CHOP is not part of the University of Pennsylvania Health System. [citation needed] The Chester County Hospital and Health System joined Penn Medicine in 2013. [3]
In this study, the complete response rate (presumed to be temporary) to a standard CHOP chemotherapeutic regimen (i.e. cyclophosphamide doxorubicin, vincristine, and prednisone) was only 10% whereas a more intensive CHO chemotherapy regimen which included high dose methotrexate and bleomycin achieved a compete response rate (presumed temporary ...
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