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Hyperkeratinization (American English or hyperkeratinisation in British) is a disorder of the cells lining the inside of a hair follicle. It is the normal function of these cells to detach or slough off from the skin lining at normal intervals. The dead cells are then forced out of the follicle (primarily by the growing hair).
Epidermolytic hyperkeratosis (also known as "Bullous congenital ichthyosiform erythroderma," [7] "Bullous ichthyosiform erythroderma," [8]: 482 or "bullous congenital ichthyosiform erythroderma of Brocq" [9]) is a rare skin disease in the ichthyosis family, affecting around 1 in 250,000 people.
Examples of non-keratinized stratified squamous epithelium include some parts of the lining of oral cavity, pharynx, conjunctiva of eye, upper one-third esophagus, rectum, vulva, and vagina. [ 3 ] Even non-keratinized surfaces, consisting as they do of keratinocytes , have a minor superficial keratinized layer of varying thickness, depending on ...
The primary function of keratinocytes is the formation of a barrier against environmental damage by heat, UV radiation, dehydration, pathogenic bacteria, fungi, parasites, and viruses.
Diagnosis is mainly clinical, based on the history and clinical appearance. The differential diagnosis includes other oral white lesions such as Leukoplakia, squamous cell carcinoma, oral candidiasis, lichen planus, white sponge nevus and contact stomatitis. [7] In contrast to pseudomembraneous candidiasis, this white patch cannot be wiped off. [7]
Non-keratinized squamous epithelium, including cornea and transitional epithelium [6] Cytokeratin 7: A subgroup of glandular epithelia and their tumors [6] Transitional epithelium and transitional carcinoma [6] Cytokeratin 8: Glandular epithelia of the digestive, respiratory and urogenital tracts, both endocrine and exocrine cells, as well as ...
Scale forms on the skin surface in various disease settings, and is the result of abnormal desquamation. In pathologic desquamation, such as that seen in X-linked ichthyosis, the stratum corneum becomes thicker (hyperkeratosis), imparting a "dry" or scaly appearance to the skin, and instead of detaching as single cells, corneocytes are shed in clusters, which forms visible scales. [2]
Epithelial cells line body surfaces, and are described according to their shape, with three principal shapes: squamous, columnar, and cuboidal. Squamous epithelium has cells that are wider than their height (flat and scale-like). Cuboidal epithelium has cells whose height and width are approximately the same (cube shaped).