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Mephentermine, sold under the brand name Wyamine among others, is a sympathomimetic medication which was previously used in the treatment of low blood pressure but is mostly no longer marketed. [6] [5] [4] [7] [8] It is used by injection into a vein or muscle, by inhalation, and by mouth. [4] [5]
In accordance with its lack of serotonin release and serotonin 5-HT 2B receptor agonism, phentermine appears to show no risk of primary pulmonary hypertension (PPH) or valvular heart disease (VHD) in humans. [32] [10] [27] Phentermine has been found to be active as an agonist of the rat and human trace amine-associated receptor 1 (TAAR1).
Chlorphentermine, sold under the brand names Apsedon, Desopimon, and Lucofen, is a serotonergic appetite suppressant of the amphetamine family. Developed in 1962, it is the para-chloro derivative of the better-known appetite suppressant phentermine, which is still in current use.
FDA approves opioid-free pain medication with 'no sign of addiction' Melissa Rudy. February 2, 2025 at 1:30 AM ... The new drug is intended for treatment of moderate to severe acute pain in adults.
Vertex Pharmaceuticals claimed in a press release that the medication can be used for many types of moderate-to-severe acute pain and has shown no evidence that it is addictive, like opioids.
In two clinical trials, tested on adults between ages 18 and 80, Journavx was found to reduce moderate to severe acute pain for adults from baseline by about 50% in 48 hours.
Phentermine is a substituted amphetamine and topiramate has an unknown mechanism of action Approved for weight management (short-term) by the FDA but not the European Medicines Agency [ 54 ] 10% [ 55 ] or 8.25 kilograms (18.2 lb) [ 56 ]
No improvement in clinical benefit; risk for death; veno-occlusive disease. [2] Pemoline (Cylert) 1997 Canada, UK Withdrawn from US in 2005 due to hepatotoxicity. [41] [3] Pentobarbital: 1980 Norway Risk of fatal overdose. [3] Pentylenetetrazol: 1982 US Withdrawn for inability to produce effective convulsive therapy, and for causing seizures.
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