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The median lethal dose (LD 50) is between 15 and 18 g/kg body weight in rats and mice, respectively, five times the LD 50 of table salt (3 g/kg in rats). The use of MSG as a food additive and the natural levels of glutamic acid in foods are not of toxic concern in humans. [20]
However, the study showed no persistent or severe effects from MSG ingestion. What's more, when the subjects who believed they had an MSG sensitivity were retested, the results weren't consistent ...
The short answer: no. MSG is a synthetic form of glutamic acid, an amino acid that’s produced naturally in the human body. There is zero difference between natural glutamic acid and MSG. Your ...
MSG took the biggest hit, with the effects of that letter rippling on throughout the decades, all over the world. Restaurants publicly swore off MSG. Food and beverage publicists begged not to be ...
The EU has not yet published an official NOAEL (no observable adverse effect level) for glutamate, but a 2006 consensus statement of a group of German experts drawing from animal studies was that a daily intake of glutamic acid of 6 grams per kilogram of body weight (6 g/kg/day) is safe. From human studies, the experts noted that doses as high ...
But in the first few hits, there are some articles that look fairly unbiased, like "Effect of systemic monosodium glutamate (MSG) on headache and pericranial muscle sensitivity" published in Cephalalgia which states that it was a "a double-blinded, placebo-controlled, crossover study to investigate the occurrence of adverse effects such as ...
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Excitotoxicity can occur from substances produced within the body (endogenous excitotoxins). Glutamate is a prime example of an excitotoxin in the brain, and it is also the major excitatory neurotransmitter in the central nervous system of mammals. [14]