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  2. Celecoxib - Wikipedia

    en.wikipedia.org/wiki/Celecoxib

    Celecoxib, sold under the brand name Celebrex among others, is a COX-2 inhibitor and nonsteroidal anti-inflammatory drug (NSAID). [7] It is used to treat the pain and inflammation in osteoarthritis , acute pain in adults, rheumatoid arthritis , psoriatic arthritis , ankylosing spondylitis , painful menstruation , and juvenile rheumatoid ...

  3. Cyclooxygenase-2 inhibitor - Wikipedia

    en.wikipedia.org/wiki/Cyclooxygenase-2_inhibitor

    In the CLASS trial which compared Celebrex 800 mg/day to ibuprofen 2400 mg/day and diclofenac 150 mg/day for osteoarthritis or rheumatoid arthritis for six months, Celebrex was associated with significantly fewer upper gastrointestinal complications (0.44% vs. 1.27%, p = 0.04), with no significant difference in incidence of cardiovascular ...

  4. Discovery and development of cyclooxygenase 2 inhibitors

    en.wikipedia.org/wiki/Discovery_and_development...

    [5] [6] It took less than eight years to develop and market the first COX-2 inhibitor, with Celebrex launched in December 1998 and Vioxx launched in May 1999. [ 7 ] [ 8 ] Celecoxib and other COX-2 selective inhibitors, valdecoxib , parecoxib , and mavacoxib , were discovered by a team at the Searle division of Monsanto led by John Talley .

  5. Sciatica - Wikipedia

    en.wikipedia.org/wiki/Sciatica

    Intraspinal, or discogenic sciatica refers to sciatica whose pathology involves the spine. In 90% of sciatica cases, this can occur as a result of a spinal disc bulge or herniation. [14] [28] Sciatica is generally caused by the compression of lumbar nerves L4 or L5 or sacral nerve S1. [29] Less commonly, sacral nerves S2 or S3 may cause ...

  6. The best back braces of 2024 for slipped discs, sciatica and more

    www.aol.com/lifestyle/best-back-braces-185356472...

    From slipped disc to sciatica to lumbar support, these are the best back braces of 2025. ... While the causes vary, the symptoms can range from a dull ache to sharp pain or even radiating pain ...

  7. 3 Reasons Pfizer, Inc. Can Overcome Celebrex Patent Loss - AOL

    www.aol.com/news/2014-03-13-3-reasons-pfizer-inc...

    As Celebrex is Pfizer's fourth best-selling drug, raking in $2.9 billion in revenue in 2013 and showing stellar growth year over year of 9%, it's understandable if this court decision rattles ...

  8. Nonsteroidal anti-inflammatory drug - Wikipedia

    en.wikipedia.org/wiki/Nonsteroidal_anti...

    Non-steroidal anti-inflammatory drugs [1] [3] (NSAID) [1] are members of a therapeutic drug class which reduces pain, [4] decreases inflammation, decreases fever, [1] and prevents blood clots. Side effects depend on the specific drug, its dose and duration of use, but largely include an increased risk of gastrointestinal ulcers and bleeds ...

  9. Sciatic nerve - Wikipedia

    en.wikipedia.org/wiki/Sciatic_nerve

    Pain caused by compression or irritation of the sciatic nerve by a problem in the lower back is called sciatica. Common causes of sciatica include the following lower back and hip conditions: spinal disc herniation, degenerative disc disease, lumbar spinal stenosis, spondylolisthesis, and piriformis syndrome. [5]

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