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The metanephrogenic blastema or metanephric blastema (or metanephric mesenchyme, or metanephric mesoderm) is one of the two embryological structures that give rise to the kidney, the other being the ureteric bud. The metanephric blastema mostly develops into nephrons, but can also form parts of the collecting duct system.
After inducing the metanephric mesenchyme the lower portions of the nephric duct will migrate caudally (downward) and connect with the bladder, thereby forming the ureters. The ureters will carry urine from the kidneys to the bladder for excretion from the fetus into the amniotic sac.
Schematic representation of nephrogenesis during embryologic development following induction of cap mesenchyme by the ureteric bud. [ 169 ] The metanephros develops from the ureteric bud , which is an outgrowth on the caudal part of the nephric duct , [ 170 ] [ 171 ] and the metanephrogenic blastema , which is part of the intermediate mesoderm ...
The mechanism of multicystic dysplastic kidney is a result of an abnormal induction of metanephric mesenchyme. This could be a result of a formation difficulty of the mesonephric duct . Some mutations in genes associated with renal dysplasia (in syndromes) have been determined.
The ureteric bud, also known as the metanephric diverticulum, [1]: 50 is a protrusion from the mesonephric duct during the development of the urinary and reproductive organs. [ 2 ] [ 3 ] It later develops into a conduit for urine drainage from the kidneys, which, in contrast, originate from the metanephric blastema .
In recent studies, insight has been obtained on the genetic basis of this disease, supporting the hypothesis that MSK is due to a disruption at the 'ureteric bud-metanephric mesenchyme' interface. This explains why so many tubular defects coexist in this disease, and particularly a distal tubular acidification defect of which the highly ...
Intermediate mesoderm or intermediate mesenchyme is a narrow section of the mesoderm (one of the three primary germ layers) located between the paraxial mesoderm and the lateral plate of the developing embryo. [1] The intermediate mesoderm develops into vital parts of the urogenital system (kidneys, gonads and respective tracts).
A supernumerary kidney is an additional kidney to the number usually present in an organism. This often develops as the result of splitting of the nephrogenic blastema, or from separate metanephric blastemas into which partially or completely reduplicated ureteral stalks enter to form separate capsulated kidneys; in some cases the separation of the reduplicated organ is incomplete (fused ...