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A myelodysplastic syndrome (MDS) is one of a group of cancers in which blood cells in the bone marrow do not mature, and as a result, do not develop into healthy blood cells. [3] Early on, no symptoms typically are seen. [3] Later, symptoms may include fatigue, shortness of breath, bleeding disorders, anemia, or frequent infections. [3]
Mitochondrial DNA depletion syndrome (MDS or MDDS), or Alper's disease, is any of a group of autosomal recessive disorders that cause a significant drop in mitochondrial DNA in affected tissues. Symptoms can be any combination of myopathic , hepatopathic , or encephalomyopathic . [ 1 ]
MDS information is transmitted electronically by nursing homes to the MDS database in their respective states. MDS information from the state databases is captured into the national MDS database at Centers for Medicare and Medicaid Services (CMS). Sections of MDS (Minimum Data Set): Identification Information; Hearing, Speech and Vision
Myelodysplastic–myeloproliferative diseases are a category of hematological malignancies which have characteristics of both myelodysplastic and myeloproliferative conditions.
Due to the scoring system being developed for MDS, the more myeloproliferative cases of CMML (WBC >13x10 9) are excluded from the scoring system. Although the IPSS scoring system is used clinically, there is a high variability in each group. For this reason, new modalities for assessing prognosis in MDS (and CMML) are being developed. [12] [24]
The International Prognostic Scoring System (IPSS), originally published in 1997, is used by many doctors to help assess the severity of a patient's myelodysplastic syndrome (MDS). Based on the IPSS score, the patient's history, and the physician's own personal observations, the physician will design a treatment plan to address the MDS.
As there are a number of drawbacks brought by frequent transfusions, directly treating the cause of anemia (e.g. myelodysplastic syndrome), if available, remains the optimal choice of treatment. [3] Hematopoietic stem cell transplantation is a treatment for thalassemia that minimizes the need of transfusion in long term.
MDS: myelodysplastic syndrome: ME: UK: Myalgic Encephalopathy ( = Chronic Fatigue Syndrome or "CFS") M/E: microscopic examination MEC: Moderate emetic chemotherapy: MEDLINE: Medical Literature Analysis and Retrieval System Online (U.S. National Library of Medicine) MELD: Model for End-Stage Liver Disease: MEN: multiple endocrine neoplasia: MeSH