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In the pharmaceutical industry, drug dissolution testing is routinely used to provide critical in vitro drug release information for both quality control purposes, i.e., to assess batch-to-batch consistency of solid oral dosage forms such as tablets, and drug development, i.e., to predict in vivo drug release profiles. [1]
Tilling the soil, or tillage, is the breaking of soil, such as with a plough or harrow, to prepare the soil for new seeds. Tillage systems vary in intensity and disturbance. Conventional tillage is the most intense tillage system and disturbs the deepest level of soils. At least 30% of plant residue remains on the soil surface in conservation ...
Fast dissolution is not always ideal. For example, slow dissolution rates can prolong the duration of action or avoid initial high plasma levels. Treatment of active ingredient by special ways such as spherical crystallization [2] can have some advantages for drug formulation.
Synthetic polymers began replacing other chemical binders for soil stabilization in agriculture in the late 20th century. [1] Compared to traditional chemical binders, polymer soil additives can achieve the same amount of strengthening at much lower concentrations – for example, mixtures of 0.5-1% of various biopolymers have strength levels that match or exceed those of 10% cement mixtures ...
A soil test is a laboratory or in-situ analysis to determine the chemical, physical or biological characteristics of a soil. Possibly the most widely conducted soil tests are those performed to estimate the plant-available concentrations of nutrients in order to provide fertilizer recommendations in agriculture.
Friability and abrasion testing is performed in rotating testing drums, designed according to the pharmacopeia. The measured parameter is weight loss before and after testing and tumbling the tablets at a particular time and speed. In the friability test drum tablets are being carried up by a "shovel" and dropped.
Soil stabilization is a general term for any physical, chemical, mechanical, biological, or combined method of changing a natural soil to meet an engineering purpose. [1] Improvements include increasing the weight-bearing capabilities, tensile strength, and overall performance of unstable subsoils , sands, and waste materials in order to ...
In pharmaceutics, sink condition is a term mostly related to the dissolution testing procedure.. It means using a sheer volume of solvent, usually about 5 to 10 times greater than the volume present in the saturated solution of the targeted chemical (often the API, and sometimes the excipients) contained in the dosage form being tested.