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AOH1996 was created to target a post-translationally modified isoform of PCNA, termed caPCNA, which is preferentially found in cancer cells. PCNA is crucial in the body for DNA repair , but targeting it is difficult because of its role in healthy cells.
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18538 Ensembl ENSG00000132646 ENSMUSG00000027342 UniProt P12004 P17918 RefSeq (mRNA) NM_182649 NM_002592 NM_011045 RefSeq (protein) NP_002583 NP_872590 NP_035175 Location (UCSC) Chr 20: 5.11 – 5.13 Mb Chr 2: 132.09 – 132.1 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse Cryo-EM structure of the DNA-bound PolD–PCNA processive complex Proliferating cell nuclear antigen (PCNA) is ...
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Promising results of health and medical research are reported: mice- and dogs-tested AOH1996 against cancer growth and for combination with other anti-cancer agents (1 Aug), [414] a mice-tested engineered probiotic against autoimmunity in the brain as in multiple sclerosis (9 Aug), [415] mice-tested engineered bacteria to detect cancer DNA (10 ...
1 News articles about this drug are factually incorrect if you read the original article in Cell
The United States (USA) was the host nation for the 1996 Summer Olympics in Atlanta. 646 competitors, 375 men and 271 women, took part in 263 events in 31 sports. [1]With a total of 44 gold, 32 silver, and 25 bronze medals, the United States returned to the top spot in the medal standings for the first time since 1984, and for the first time since 1968 in a non-boycotted Summer Olympics.
North Carolina's 4th district: Fred Heineman lost to David Price in a rematch of the 1994 election. Ohio's 6th district: Frank Cremeans lost to Ted Strickland; Ohio's 10th district: Martin Hoke lost to Dennis Kucinich; Oregon's 5th district: Jim Bunn lost to Darlene Hooley; Texas's 9th district: Steve Stockman lost to Nick Lampson