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The Office of Dietary Supplements recommends daily vitamin D intakes of 600 IU (15 mcg) for adults ages 19 to ... (ULs) of what is safe to consume. People 9 and older, for example, may have a ...
Based on risk assessment, a safe upper intake level of 250 μg (10,000 IU) per day in healthy adults has been suggested by non-government authors. [ 5 ] [ 6 ] Blood levels of 25-hydroxyvitamin D necessary to cause adverse effects in adults are thought to be greater than about 150 ng/mL, leading the Endocrine Society to suggest an upper limit ...
In the UK: a ‘Safe Intake’ (SI) of 8.5–10 μg/d (340–400 IU/d) for infants < 1 year (including exclusively breastfed infants) and an SI of 10 μg/d (400 IU/d) for children aged 1 to <4 years; for all other population groups aged 4 years and more (including pregnant/lactating women) a Reference Nutrient Intake (RNI) of day10 μg (400 IU ...
The European Menopause and Andropause Society recommends postmenopausal women consume 15 μg (600 IU) until age 70, and 20 μg (800 IU) from age 71. This dose should be increased to 100 μg (4,000 IU) in some patients with very low vitamin D status or in case of co-morbid conditions.
In that study, the compliance calculation could be questionable since only random samples of the returned medications were counted. In a study by De Niet et al., [72] 60 subjects with vitamin D deficiency were randomized to receive 2000 IU vitamin D3 daily or 50 000 IU monthly. They reported a similar efficacy of the two dosing frequencies ...
At a typical intake of cholecalciferol (up to 2000 IU/day), conversion to calcifediol is rapid. When large doses are given (100,000 IU), it takes 7 days to reach peak calcifediol concentrations. [9] Calcifediol binds in the blood to vitamin D-binding protein (also known as gc-globulin) and is the main circulating vitamin D metabolite.
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