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Common side effects include nausea, abdominal pain, and constipation. [2] It may worsen the symptoms of asthma. [2] Propranolol may cause harmful effects for the baby if taken during pregnancy; [7] however, its use during breastfeeding is generally considered to be safe. [8] It is a non-selective beta blocker which works by blocking β ...
Inderal (propranolol) – a beta blocker; it is used for acute anxiety, panic attacks, and hypertension; Intuniv - an extended release, non-stimulant alpha-2 adrenergic agonist used to treat attention deficit hyperactivity
The neuropsychiatric side effects of some beta blockers (e.g. sleep disruption, insomnia) may be due to this effect. [99] Some pre-clinical and clinical research suggests that some beta blockers may be beneficial for cancer treatment. [100] [101] However, other studies do not show a correlation between cancer survival and beta blocker usage.
The consensus is to reduce dosage gradually over several weeks, e.g. 4 or more weeks for diazepam doses over 30 mg/day, [1] with the rate determined by the person's ability to tolerate symptoms. [120] The recommended reduction rates range from 50% of the initial dose every week or so, [121] to 10–25% of the daily dose every 2 weeks. [120]
Panic disorder is a mental and behavioral disorder, [5] specifically an anxiety disorder characterized by reoccurring unexpected panic attacks. [1] Panic attacks are sudden periods of intense fear that may include palpitations, sweating, shaking, shortness of breath, numbness, or a feeling that something terrible is going to happen.
Panic disorder is strikingly different from other types of anxiety disorders in that panic attacks are often sudden and unprovoked. [31] However, panic attacks experienced by those with panic disorder may also be linked to or heightened by exposure to certain places or situations, making daily life difficult. [32]
Comorbid depression (lifetime prevalence) is seen in 20-70% of those with social anxiety disorder, 50% of those with panic disorder and 43% of those with general anxiety disorder. The 12 month prevalence of alcohol or substance use disorders in those with anxiety disorders is 16.5%.
A systematic review of 63 trials with over 35,000 participants indicated β-blockers increased the risk of mortality, compared to other antihypertensive therapies. [15] They do, however, have an important role in the prevention of heart attacks in people who have already had a heart attack. [37]
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