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Phenotypic screening is a type of screening used in biological research and drug discovery to identify substances such as small molecules, peptides, or RNAi that alter the phenotype of a cell or an organism in a desired manner. [1]
E. O. Wilson defined sociobiology as "the extension of population biology and evolutionary theory to social organization". [6]Sociobiology is based on the premise that some behaviors (social and individual) are at least partly inherited and can be affected by natural selection. [7]
Phenotypic variation (due to underlying heritable genetic variation) is a fundamental prerequisite for evolution by natural selection. It is the living organism as a whole that contributes (or not) to the next generation, so natural selection affects the genetic structure of a population indirectly via the contribution of phenotypes.
A suppressor screen is used to identify suppressor mutations that alleviate or revert the phenotype of the original mutation, in a process defined as synthetic viability. [13] Suppressor mutations can be described as second mutations at a site on the chromosome distinct from the mutation under study, which suppress the phenotype of the original ...
[76] [71] Such display and the resulting favorable attention can improve a hunter's reputation by providing information about his phenotypic quality. High quality signallers are more successful in acquiring mates and allies. Thus, costly signalling theory can explain apparently wasteful and altruistic behaviour. [28] [36] [75] [77] [78] [28] [79]
Genetic architecture is incredibly important for understanding evolutionary theory because it describes phenotypic variation in its underlying genetic terms, and thus it gives us clues about the evolutionary potential of these variations. Therefore, genetic architecture can help us to answer biological questions about speciation, the evolution ...
A phenotypic trait is an obvious, observable, and measurable characteristic of an organism; it is the expression of genes in an observable way. An example of a phenotypic trait is a specific hair color or eye color. Underlying genes, that make up the genotype, determine the hair color, but the hair color observed is the phenotype.
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