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Gigantism (Greek: γίγας, gígas, "giant", plural γίγαντες, gígantes), also known as giantism, is a condition characterized by excessive growth and height significantly above average. In humans, this condition is caused by over-production of growth hormone in childhood.
Specialty: Endocrinology: Symptoms: Enlargement of the hands, feet, forehead, jaw, and nose, thicker skin, deepening of the voice [3]: Complications: Type 2 diabetes, sleep apnea, high blood pressure, [3] high cholesterol, heart problems, particularly enlargement of the heart (cardiomegaly), osteoarthritis, spinal cord compression or fractures, increased risk of cancerous tumors, precancerous ...
Local gigantism affecting second toe of a child Local gigantism or localised gigantism is a condition in which a certain part of the body acquires larger than normal size due to excessive growth of the anatomical structures or abnormal accumulation of substances.
Laron syndrome (LS), also known as growth hormone insensitivity or growth hormone receptor deficiency (GHRD), is an autosomal recessive disorder characterized by a lack of insulin-like growth factor 1 (IGF-1; somatomedin-C) production in response to growth hormone (GH; hGH; somatotropin). [6]
GH treatment usually decreases insulin sensitivity, [24] but some studies showed no evidence for increased diabetes incidence in GH-treated adult hypopituitary patients. [ 25 ] In past it was believed that GH treatment could increase the cancer risk; a large study recently concluded that "With relatively short follow-up, the overall primary ...
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Hyperpituitarism is a condition due to the primary hypersecretion of pituitary hormones; [3] [medical citation needed] it typically results from a pituitary adenoma.In children with hyperpituitarism, disruption of growth regulation is rare, either because of hormone hypersecretion or because of manifestations caused by local compression of the adenoma.
Treatment Depends on type Autoimmune polyendocrine syndromes ( APSs ), also called polyglandular autoimmune syndromes ( PGASs ) [ 3 ] or polyendocrine autoimmune syndromes ( PASs ), are a heterogeneous group [ 4 ] of rare diseases characterized by autoimmune activity against more than one endocrine organ , although non-endocrine organs can be ...