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Leiomyoma enucleated from a uterus. External surface on left; cut surface on right. Micrograph of a small, well-circumscribed colonic leiomyoma arising from the muscularis mucosae and showing fascicles of spindle cells with eosinophilic cytoplasm and elongated, cigar-shaped nuclei Immunohistochemistry for β-catenin in uterine leiomyoma, which is negative as there is only staining of cytoplasm ...
Fibrodysplasia ossificans progressiva (/ ˌ f aɪ b r oʊ d ɪ ˈ s p l eɪ ʒ (i) ə ɒ ˈ s ɪ f ɪ k æ n z p r ə ˈ ɡ r ɛ s ɪ v ə /; [1] abbr. FOP), also called Münchmeyer disease or formerly myositis ossificans progressiva, is an extremely rare connective tissue disease in which fibrous connective tissue such as muscle, tendons, and ligaments turn into bone tissue (ossification).
Fibrous dysplasia is a very rare [2] nonhereditary genetic disorder where normal bone and marrow is replaced with fibrous tissue, resulting in formation of bone that is weak and prone to expansion. As a result, most complications result from fracture , deformity, functional impairment, pain, and the impingement of nerves. [ 3 ]
Physiologically, fibrosis acts to deposit connective tissue, which can interfere with or totally inhibit the normal architecture and function of the underlying organ or tissue. Fibrosis can be used to describe the pathological state of excess deposition of fibrous tissue, as well as the process of connective tissue deposition in healing. [4]
There are two main types of myoma: Leiomyomas which occur in smooth muscle. [1] They most commonly occur as uterine fibroids, but may also form in other locations. Rhabdomyomas which occur in striated muscle. [1] [2] [3] They are rare tumors. So-called adult rhabdomyoma has been diagnosed mostly in men aged >40 years, whereas fetal rhabdomyoma ...
The fibrous layer is of dense irregular connective tissue, containing fibroblasts, while the cambium layer is highly cellular containing progenitor cells that develop into osteoblasts. [3] These osteoblasts are responsible for increasing the width of a long bone (the length of a long bone is controlled by the epiphyseal plate ) and the overall ...
The gomphosis is the only joint-type in which a bone does not join another bone, as teeth are not technically bone. In modern, more anatomical, joint classification, the gomphosis is simply considered a fibrous joint because the tissue linking the structures is ligamentous.
It is usually around 1–2 cm in size, but be as large as 7 cm. [3] They consist of foci consist of collagen rich connective tissue, fibroblasts, histiocytes and osteoclasts. [2] Usually no treatment is required. [1] Surgical curettage and bone grafting may be required if it is large. [3]