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  2. Phosphodiesterase inhibitor - Wikipedia

    en.wikipedia.org/wiki/Phosphodiesterase_inhibitor

    Phosphodiesterase-5. A phosphodiesterase inhibitor is a drug that blocks one or more of the five subtypes of the enzyme phosphodiesterase (PDE), thereby preventing the inactivation of the intracellular second messengers, cyclic adenosine monophosphate (cAMP) and cyclic guanosine monophosphate (cGMP) by the respective PDE subtype(s).

  3. Crisaborole - Wikipedia

    en.wikipedia.org/wiki/Crisaborole

    Crisaborole was approved for use in the United States in December 2016 [14] [1] and for use in Canada in June 2018. [15] The safety and efficacy of crisaborole were established in two placebo-controlled trials with a total of 1,522 participants ranging in age from two years of age to 79 years of age, with mild to moderate atopic dermatitis. [1]

  4. PDE5 inhibitor - Wikipedia

    en.wikipedia.org/wiki/PDE5_inhibitor

    Chemical structure of sildenafil (Viagra), the prototypical PDE5 inhibitor. A phosphodiesterase type 5 inhibitor (PDE5 inhibitor) is a vasodilating drug that works by blocking the degradative action of cGMP-specific phosphodiesterase type 5 (PDE5) on cyclic GMP in the smooth muscle cells lining the blood vessels supplying various tissues.

  5. 24-Hour Stores Near Me: 40 Places Open Right Now - AOL

    www.aol.com/finance/24-hour-stores-near-40...

    In 1963, a 7-Eleven store near an Austin, Texas, university began to stay open all night for student shoppers. It was such a success that other stores in the chain adopted the 24/7 hours, and ...

  6. Discovery and development of phosphodiesterase 5 inhibitors

    en.wikipedia.org/wiki/Discovery_and_development...

    PDE enzymes are composed of 3 functional domains: an N-terminal cyclin fold domain, a linker helical domain and a C-terminal helical bundle domain (see figure 3). [9] The active site is a deep pocket at the junction of the 3 subdomains and is lined with highly conserved residues between isotypes of PDE. [14]

  7. PDE3 inhibitor - Wikipedia

    en.wikipedia.org/wiki/PDE3_inhibitor

    RPL-554 is an analog of trequinsin, and like trequinsin, is a dual inhibitor of the phosphodiesterase enzymes PDE-3 and PDE-4. [8] As of October 2015, inhaled RPL-554 delivered via a nebulizer was in development for COPD and had been studied in asthma.

  8. PDE4 inhibitor - Wikipedia

    en.wikipedia.org/wiki/PDE4_inhibitor

    [24] [25] It was approved by the FDA on December 14, 2016 under the brand name Eucrisa for the treatment of mild-to-moderate atopic dermatitis (eczema) in patients 2 years of age and older. [26] Caffeine is a weak, non-selective PDE inhibitor. [27] A metabolite of caffeine, theophylline, is a more potent PDE inhibitor. [27]

  9. Preferred provider organization - Wikipedia

    en.wikipedia.org/wiki/Preferred_provider...

    In U.S. health insurance, a preferred provider organization (PPO), sometimes referred to as a participating provider organization or preferred provider option, is a managed care organization of medical doctors, hospitals, and other health care providers who have agreed with an insurer or a third-party administrator to provide health care at ...