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Laxatives vary as to how they work and the side effects they may have. Certain stimulant, lubricant, and saline laxatives are used to evacuate the colon for rectal and bowel examinations, and may be supplemented by enemas under certain circumstances. Sufficiently high doses of laxatives may cause diarrhea.
Phenolphthalein is slightly soluble in water and usually is dissolved in alcohols in experiments. It is a weak acid, which can lose H + ions in solution. The nonionized phenolphthalein molecule is colorless and the double deprotonated phenolphthalein ion is fuchsia. Further proton loss in higher pH occurs slowly and leads to a colorless form.
Liquid paraffin is primarily used as a pediatric laxative in medicine and is a popular treatment for constipation and encopresis. [1] Because of its ease of titration, the drug is convenient to synthesize.
Side effects are uncommon and typically mild, [1] and may include stomach pain, abdominal cramps or diarrhea, [1] Efficacy decreases with long-term use, and may cause poor bowel function. [9] Serious allergic reactions may occur with the drug. The most severe side effect of docusate, although very rare, is rectal bleeding. [23]
Phenolphthalein does not directly participate in this process; instead, it acts as an external source of electrons. In its reaction with hydrogen peroxide, the heme center of hemoglobin behaves as a peroxidase, reducing the peroxide to water. This activity depletes hemoglobin of electrons that are, in turn, re-supplied by the phenolphthalein.
Some drugs need to be used with caution in patients with renal dysfunction. The use of nitrofurantoin is contraindicated in patients with an estimated GFR of less than 30 mL/min/1.73m 2 as drug accumulation can lead to increased side effects and impaired recovery of the urinary tract, increasing the risk of treatment failure. [29]
Cialis has several common side effects, many of which also happen with other drugs used to treat ED, like sildenafil (generic Viagra®), vardenafil , and avanafil (Stendra®).
Macrogol 4000, pharmaceutical quality. Macrogol 3350, often in combination with electrolytes, is used for short-term relief of constipation as well as for long-term use in constipation of various causes, including in multiple sclerosis and Parkinson's disease patients (an often-overlooked non-motor symptom) as well as constipation caused by pharmaceutical drugs such as opioids and ...