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Chondroitin sulfate; Dermatan sulfate; Chondroitin as a supplement is now commonly used (often in combination with glucosamine) in treating the joint disease of osteoarthritis. [2] In contrast to the symptomatic treatments, chondroitin can modify the progression of a disease process in the patient which it can be used as an alternative medicine ...
Chondroitin sulfate is a sulfated glycosaminoglycan (GAG) [1] composed of a chain of alternating sugars (N-acetylgalactosamine and glucuronic acid). It is usually found attached to proteins as part of a proteoglycan. [1] A chondroitin chain can have over 100 individual sugars, each of which can be sulfated in variable positions and quantities.
Use of chondroitin in routine clinical practice should therefore be discouraged." Also in 2007, Bruyere et al. [45] without using explicit methodology for reviewing trials concluded "there is compelling evidence that glucosamine sulfate and chondroitin sulfate may interfere with progression of OA." The effectiveness of glucosamine is controversial.
[4] [5] When chondroitin sulfate proteoglycans are bonded to their side chains called chondroitin sulfate glycosaminoglycans, these molecules are known to prevent neural restoration to the damaged region of the central nervous system because they form glial scar tissue which inhibits both neuroplasticity and repair of damaged axons.
Dermatan sulfate is a glycosaminoglycan (formerly called a mucopolysaccharide) found mostly in skin, but also in blood vessels, heart valves, tendons, and lungs.. It is also referred to as chondroitin sulfate B, [1] although it is no longer classified as a form of chondroitin sulfate by most sources.
Chondroitin sulfate proteoglycans (CSPGs) are proteoglycans consisting of a protein core and a chondroitin sulfate side chain. They are known to be structural components of a variety of human tissues, including cartilage , and also play key roles in neural development and glial scar formation.
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