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The disadvantage of fomepizole is that it is expensive. Costing US$1,000 per gram, an average course used in an adult poisoning would cost approximately $3,500 to $4,000. [39] [40] Despite the cost, fomepizole is gradually replacing ethanol as the antidote of choice in ethylene glycol poisoning. [37] [38]
The 1985 Austrian diethylene glycol wine scandal (German: Glykolwein-Skandal) was an incident in which several Austrian wineries illegally adulterated their wines using the toxic substance diethylene glycol (a minor ingredient in some brands of antifreeze) to make the wines taste sweeter and more full-bodied in the style of late harvest wines. [1]
Ethylene glycol (IUPAC name: ethane-1,2-diol) is an organic compound (a vicinal diol [7]) with the formula (CH 2 OH) 2.It is mainly used for two purposes: as a raw material in the manufacture of polyester fibers and for antifreeze formulations.
The cost of cattle and pig culling exceeded €4M, compensation for lost revenue was estimated to be €200M. [60] [61] 2008 – In Italy, it was discovered that additives included substances like sulfuric acid and hydrochloric acid had been used to dilute wines. [62] 2008 – In Italy, dioxin was found in buffalo milk from farms in Caserta.
The U.S. Code of Federal Regulations allows no more than 0.2% of diethylene glycol in polyethylene glycol when the latter is used as a food additive. [11] In Australia , it is only allowed at less than 0.25% w/w of DEG as an impurity in polyethylene glycol (PEG), [ 12 ] even in toothpaste.
Family matriarch Diane Staudte and her daughter, Rachel Staudte, committed the crimes together using antifreeze purchased off the internet, with the rationale that antifreeze sold online would not contain the added bittering agent in commercial chemicals making the ethylene glycol poison detectable.
Bitterants are used in antifreeze to prevent pet and child poisonings. [1] It is required by law in some places (France, Oregon, etc.). Gas dusters often use a bitterant to discourage inhalant abuse, although this can cause problems for legitimate users. The bitterant not only leaves a bitter flavor in the air, but also leaves a bitter residue ...
Since the 1990s, several mass poisonings from toxic cough syrup have occurred in developing countries. In these cases, an ingredient in cough syrup, glycerine (glycerol), was replaced with diethylene glycol, a cheaper alternative to glycerine for industrial applications.