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The C-terminal region of XPF includes the active site residues for nuclease activity. [12] Most of the ERCC1 protein is related at the sequence level to the C-terminus of the XPF protein, [13] but residues in the nuclease domain are not present. A DNA binding “helix-hairpin-helix” domain at the C-terminus of each protein.
Exeresis may refer to the surgical removal of any part or organ, roughly synonymous to excision. [1] However, it may specifically refer to clearing the uterus of its contents after a miscarriage , such as vacuum aspiration .
DNA can be damaged by ultraviolet radiation, toxins, radioactive substances, and reactive biochemical intermediates like free radicals.The ERCC6 protein is involved in repairing the genome when specific genes undergoing transcription (dubbed active genes) are inoperative; as such, ERCC6 serves as a transcription-coupled excision repair protein, being one of the fundamental enzymes in active ...
Excision may refer to: In surgery, the partial removal of an organ, tissue, bone or tumor from a body; Type II female genital mutilation; A term used by the Australian government as part of its definition of the Australian migration zone; Excision theorem in algebraic topology, a branch of mathematics
These are retained after the surgery and examined microscopically by a pathologist to see if the margin is indeed free from tumor cells (called "negative"). If cancerous cells are found at the edges (called "positive") the operation is much less likely to achieve the desired results.
Prostatectomy (from the Greek προστάτης prostátēs, "prostate" and ἐκτομή ektomē, "excision") is the surgical removal of all or part of the prostate gland. This operation is done for benign conditions that cause urinary retention, as well as for prostate cancer and for other cancers of the pelvis.
There are two forms of CCPDMA surgery: Mohs surgery and surgical excision coupled with margin assessment. Other examples of CCPDMA are found in classical pathology textbooks as techniques of cutting surgical specimens to allow the examination of the inferior and lateral margins of typically elliptical surgical specimens.
Electrodesiccation and curettage (EDC, ED & C, or ED+C) is a medical procedure commonly performed by dermatologists, surgeons and general practitioners for the treatment of basal cell cancers and squamous cell cancers of the skin. [1]