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One unusual cause of focal hyperalgesia is platypus venom. [5] Long-term opioid (e.g. heroin, morphine) users and those on high-dose opioid medications for the treatment of chronic pain may experience hyperalgesia and experience pain out of proportion to physical findings; this is a common cause for loss of efficacy of these medications over time.
An opioid overdose results from over-activation of these receptors, which can cause permanent brain damage from cerebral hypoxia or neurotoxicity. [ 33 ] [ 7 ] Mu receptors have an analgesic effect on the brain, and are found in various parts of the nervous system including the cerebral cortex and thalamus . [ 16 ]
Opioid-induced hyperalgesia (OIH) or opioid-induced abnormal pain sensitivity, also called paradoxical hyperalgesia, is an uncommon condition of generalized pain caused by the long-term use of high dosages of opioids [1] such as morphine, [2] oxycodone, [3] and methadone.
If you decide to go for a jog in humid, 95-degree weather this summer, your body and brain could start to have some strange reactions.
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In 1986, it was presumed that permanent brain damage may result from chronic use of benzodiazepines similar to alcohol-related brain damage. [70] In 1987, 17 inpatient people who used high doses of benzodiazepines non-medically have anecdotally shown enlarged cerebrospinal fluid spaces with associated cerebral atrophy. Cerebral atrophy ...
Hot flashes, night sweats, and heat sensitivity can be a sign of hyperthyroidism, hormonal changes, or menopause. Here, experts share potential causes. ... Here, experts share potential causes ...
It occurs when exposure to a substance – specifically, a neurotoxin or neurotoxicant– alters the normal activity of the nervous system in such a way as to cause permanent or reversible damage to nervous tissue. [1] This can eventually disrupt or even kill neurons, which are cells that transmit and process signals in the brain and other ...