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Clark's rule is a medical term referring to a mathematical formula used to calculate the proper dosage of medicine for children aged 2–17 based on the weight of the patient and the appropriate adult dose. [1] The formula was named after Cecil Belfield Clarke (1894–1970), a Barbadian physician who practiced throughout the UK, the West Indies ...
However, the names of all SI mass units are based on gram, rather than on kilogram; thus 10 3 kg is a megagram (10 6 g), not a *kilokilogram. The tonne (t) is an SI-compatible unit of mass equal to a megagram (Mg), or 10 3 kg. The unit is in common use for masses above about 10 3 kg and is often used with SI prefixes.
Drugs come with a recommended dose in milligrams or micrograms per kilogram of body weight, and that is used in conjunction with the patient's age and body weight to determine a safe dose. In single-dose scenarios, the patient's body weight and the drug's recommended dose per kilogram are used to determine a safe one-time dose.
The LD 50 is usually expressed as the mass of substance administered per unit mass of test subject, typically as milligrams of substance per kilogram of body mass, sometimes also stated as nanograms (suitable for botulinum), micrograms, or grams (suitable for paracetamol) per kilogram. Stating it this way allows the relative toxicity of ...
The parameter also indicates the theoretical volume of plasma from which a substance would be completely removed per unit time. Usually, clearance is measured in L/h or mL/min. [2] Excretion, on the other hand, is a measurement of the amount of a substance removed from the body per unit time (e.g., mg/min, μg/min, etc.). While clearance and ...
Cholinesterase inhibition was observed at all dose levels tested, and a NOAEL of 0.03 mg/kg/day estimated by dividing a LOAEL of 0.3 mg/kg/day by an uncertainty factor of 10. As with the acute RfD, the chronic RfD of 3×10 −4 mg/kg/day was determined by dividing this NOAEL by the inter- and intraspecies uncertainty factors.
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0.1 × ( 12 ÷ 8 ) = 0.15 grain per dscf when corrected to a gas having a specified reference CO 2 content of 12 volume %. Notes: Although ppmv and grains per dscf have been used in the above examples, concentrations such as ppbv (i.e., parts per billion by volume), volume percent, grams per dscm and many others may also be used.
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