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HLA-B27 is implicated in other types of seronegative spondyloarthropathy, such as reactive arthritis, acute anterior uveitis, iritis, Crohn's and ulcerative colitis associated spondyloarthritis. The shared association with HLA-B27 leads to increased clustering of these diseases. [10] [11] HLA antigens have been studied in relation to autism. [12]
HLA region of Chromosome 6. The human leukocyte antigen (HLA) system is a complex of genes on chromosome 6 in humans that encode cell-surface proteins responsible for regulation of the immune system. [1] The HLA system is also known as the human version of the major histocompatibility complex (MHC) found in many animals. [2]
n/a Ensembl ENSG00000228964 ENSG00000234745 ENSG00000206450 ENSG00000224608 ENSG00000223532 ENSG00000232126 n/a UniProt P01889 n/a RefSeq (mRNA) NM_005514 n/a RefSeq (protein) NP_005505 n/a Location (UCSC) Chr 6: 31.35 – 31.37 Mb n/a PubMed search n/a Wikidata View/Edit Human HLA-B (major histocompatibility complex, class I, B) is a human gene that provides instructions for making a protein ...
Human leukocyte antigen (HLA) alleles associated with conditions of or affecting the human integumentary system Condition Associated HLA allele(s) Fixed drug eruption: B22 Lichen planus: DR1 DR2 DRw9 DR10 Bw15 B8 Psoriasis: Cw6 DR406 Psoriatic arthritis: B27 Ankylosing spondylitis: B27 Reactive arthritis: B27 Acute anterior uveitis: B27 Behçet ...
Namely, in 1962 van Rood analyzed reaction patterns of 60 sera against leucocytes from 100 donors and detected a seemingly diallelic system of two leucocyte antigens which he called 4a and 4b (later known as HLA-Bw4 and HLA-Bw6 [8]), while Payne with collaborators in 1964 detected two leucocyte antigen LA1 and LA2 (later HLA-A1 and HLA-A2 ...
The association of AS with HLA-B27 suggests the condition involves CD8 T cells, which interact with HLA-B. [22] This interaction is not proven to involve a self-antigen, and at least in the related reactive arthritis, which follows infections, the antigens involved are likely to be derived from intracellular microorganisms. [7]
The second step comprises two sections that are assessed independently according to the existence of either sacroiliitis on imaging or human leukocyte antigen (HLA) B27: [6] HLA-B27-positive people — To diagnose axial spondyloarthritis in those who test positive for HLA-B27, at least two more spondyloarthritis symptoms from the list below ...
The blood tests may measure levels of inflammatory markers, as well as the presence of specific immune markers which may include anti-nuclear antibody, HLA-B27, rheumatoid factor and anti–citrullinated protein antibody. These serological markers may be negative in children with JIA, and are often present in healthy children; as such they ...