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Erythema toxicum neonatorum is a common, non-threatening rash in newborns. [1] [2] It appears in 40-70% of newborns within the first week of life, and it typically improves within 1–2 weeks. [2] [3] [4] It only occurs during the newborn period, but may appear slightly later in premature babies. [2] [5] The rash has a
Transient neonatal pustular melanosis (TNPM), also known as pustular melanosis, is a type of neonatal pustular eruption that is a transient rash common in newborns.It is vesiculopustular rash made up of 1–3 mm fluid-filled lesions that rupture, leaving behind a collarette of scale and a brown macule. [3]
Blood disorders, such as hereditary spherocytosis and hemolytic disease of the newborn, that increase extramedullary hemotopoeisis can also cause a blueberry muffin baby. It is also possible that a neonate with the blueberry muffin rash can have an underlying malignancy such as metastatic neuroblastoma and congenital leukemia . [ 6 ]
Other causes of acneiform eruptions such as those induced by the use of topical products like creams, ointments and shampoos on the skin are often ruled out before diagnosis. [7] Maternal medications like lithium and high dose corticosteroids may also induce formulation of pustules in newborns and can be assessed with a thorough family history. [8]
Neonatal lupus erythematosus is an autoimmune disease in an infant born to a mother with anti-Ro/SSA and with or without anti-La/SSB antibodies. [1] [2] The disease most commonly presents with a rash resembling subacute cutaneous lupus erythematosus and can have systemic abnormalities such as complete heart block or hepatosplenomegaly. [3]
Other skin conditions that may appear similar include erythema toxicum neonatorum, transient neonatal pustular melanosis, infantile acne, miliaria, infantile acropustulosis, and sucking blisters. [3] CNS disease may appear like bacterial or other viral meningitis's. [ 3 ]
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