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The team behind the recent study had previously shown that levothyroxine use, particularly in people it is used in unnecessarily, can have an array of unwanted side effects.
For patients taking levothyroxine, TSH may be boosted by discontinuing levothyroxine for 3–6 weeks. [6] This long period of hormone withdrawal is required because of levothyroxine's relatively long biological half-life, and may result in symptoms of hypothyroidism in the patient. The shorter half-life of liothyronine permits a withdrawal ...
Levothyroxine has a half-life of 7.5 days when taken daily, so about six weeks is required for it to reach a steady level in the blood. [5] Side effects from excessive doses include weight loss, trouble tolerating heat, sweating, anxiety, trouble sleeping, tremor, and fast heart rate. [5]
The study analyzed records of more than 125,000 adults who began taking the GLP-1 drugs liraglutide, semaglutide, or tirzepatide between January 2018 and December 2023.
Taking levothyroxine (a medication used to correct hypothyroidism) could potentially lead to hyperthyroidism during earlier stages of treatment, adds Alexander.
It is used to treat hypothyroidism, [1] but less preferred than levothyroxine. [1] It is taken by mouth. [1] Maximal effects may take up to three weeks to occur. [1] Side effects may occur from excessive doses. [1] This may include weight loss, fever, headache, anxiety, trouble sleeping, arrhythmias, and heart failure. [1]
[15] However, subgroup analysis found that patients who remain the most symptomatic while taking levothyroxine may benefit from therapy containing liothyronine. [15] There is a lack of evidence around the benefits, long-term effects and side effects of dessicated thyroid extract. It is no longer recommended for the treatment of hypothyroidism. [78]
Gad experienced a negative side effect While the initial GLP-1 agonist Gad was using helped him lose weight, he said he ultimately had to stop taking it and switch to a different one due to a side ...