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Acetazolamide, sold under the trade name Diamox among others, is a medication used to treat glaucoma, epilepsy, acute mountain sickness, periodic paralysis, idiopathic intracranial hypertension (raised brain pressure of unclear cause), heart failure and to alkalinize urine.
Machu Picchu [a] is a 15th-century Inca citadel located in the Eastern Cordillera of southern Peru on a mountain ridge at 2,430 meters (7,970 ft). [9] Often referred to as the "Lost City of the Incas", [10] it is the most familiar icon of the Inca Empire.
The Historic Sanctuary of Machu Picchu [2] is a protected area in Peru covering over 35,000 hectares. It includes the natural environment surrounding the Machu Picchu archaeological site, located in the rugged cloud forest of the Yungas on the eastern slope of the Peruvian Andes and along both banks of the Urubamba River, which flows northwest in this section.
Acetazolamide is an inhibitor of carbonic anhydrase.It is used for glaucoma, epilepsy (rarely), idiopathic intracranial hypertension, and altitude sickness. For the reduction of intraocular pressure (IOP), acetazolamide inactivates carbonic anhydrase and interferes with the sodium pump, which decreases aqueous humor formation and thus lowers IOP.
Altitude acclimatization is the process of adjusting to decreasing oxygen levels at higher elevations, in order to avoid altitude sickness. [17] Once above approximately 3,000 metres (10,000 ft) – a pressure of 70 kilopascals (0.69 atm) – most climbers and high-altitude trekkers take the "climb-high, sleep-low" approach.
Between 1904 and 1905 José María Ochoa Ladrón de Guevara, son of the owner of the hacienda Collpani, Justo Zenón Ochoa, persuaded Lizárraga to inform the discovery of Machu Picchu in Cuzco. Although Lizárraga feared losing his "fertile and abundantly productive farmland ," he accepted Ochoa's proposal after being offered new lands in ...
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The second day ascends over Dead Woman's pass- the highest point on the trail at 4,200 metres. This is the most dangerous point for altitude sickness, though little time is spent at this elevation and the trail descends again to 3,600 metres. From here, the trail only descends until arriving at Machu Picchu at 2,430 metres.