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(Reuters) -The U.S. FDA has approved Madrigal Pharmaceuticals' drug for a fatty liver disease known as non-alcoholic steatohepatitis (NASH), the first treatment to get the nod for the condition ...
The drug, Rezdiffra, was approved by the U.S. health regulator on Thursday without the need for a liver biopsy for diagnosis, paving the way for wider acceptance and creating a blockbuster ...
NASH, which can progress to liver failure, affects 5% of the U.S. population, but development of a drug for the disease has seen numerous clinical failures, most recently by Intercept Pharmaceuticals.
To encourage development and testing, the U.S. Food and Drug Administration (FDA) has issued fast track status. [ 2 ] Volixibat is an IBAT inhibitor, meaning that it blocks the function of the IBAT protein (ileal bile acid transporter), which is also called SLC10A2 (solute carrier family 10 member 2) or ASBT (apical sodium–bile acid transporter).
Treatment for MASLD is weight loss by dietary changes and exercise; [5] [14] [15] bariatric surgery can improve or resolve severe cases. [14] [16] There is some evidence for SGLT-2 inhibitors, GLP-1 agonists, pioglitazone, and vitamin E in the treatment of MASLD. [17] [18] In March 2024, resmetirom was the first drug approved by the FDA for ...
Saroglitazar (INN, trade names Lipaglyn, Bilypsa) is a drug for the treatment of type 2 diabetes mellitus, dyslipidemia, NASH and NAFLD It is approved for use in India by the Drug Controller General of India.
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