Search results
Results from the WOW.Com Content Network
Chromatin remodeling is the dynamic modification of chromatin architecture to allow access of condensed genomic DNA to the ... (for example) methylate or acetylate ...
Specific CHD complexes, such as the nucleosome remodeling deacetylase complex in C. elegans, can expose binding sites for transcriptional repressors along the chromatin by interacting with highly-modular histone tails; deacetylation of the histone residue H3K9ac is an example of how the NuRD complex can downregulate gene expression and affect ...
In molecular biology, SWI/SNF (SWItch/Sucrose Non-Fermentable), [1] [2] is a subfamily of ATP-dependent chromatin remodeling complexes, which is found in eukaryotes.In other words, it is a group of proteins that associate to remodel the way DNA is packaged.
RSC (Remodeling the Structure of Chromatin) is a member of the ATP-dependent chromatin remodeler family. The activity of the RSC complex allows for chromatin to be remodeled by altering the structure of the nucleosome. [1] There are four subfamilies of chromatin remodelers: SWI/SNF, INO80, ISW1, and CHD. [2]
Chromatin Remodeling: Chromatin remodeling can result from covalent modification of histones that physically remodel, move or remove nucleosomes. [49] Studies of Sanosaka et al. 2022, says that Chromatin remodeler CHD7 regulate cell type-specific gene expression in human neural crest cells. [50]
ADPr is an important mechanism in gene regulation that affects chromatin organization, the binding of transcription factors, and mRNA processing through poly-ADP ribose polymerase (PARP) enzymes. There are multiple types of PARP proteins, but the subclass of DNA-dependent PARP proteins including PARP-1, PARP-2, and PARP-3 interact with the ...
Chromatin remodelers in the INO80 subfamily are made of multiple subunit complexes with split ATPase domains. [3] The INO80 subfamily's protein domains are an N-terminus, two RuvB-like proteins (Rvb1 and Rvb2), and a C-terminus. [1] The ATPase domain of the N-terminus functions in the identification of DNA damage and aids in the stability of ...
Nucleosome Remodeling Factor (NURF) is an ATP-dependent chromatin remodeling complex first discovered in Drosophila melanogaster (fruit fly) that catalyzes nucleosome sliding in order to regulate gene transcription. It contains an ISWI ATPase, making it part of the ISWI family of chromatin remodeling complexes. NURF is highly conserved among ...