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In broad usage, the "practical clinical significance" answers the question, how effective is the intervention or treatment, or how much change does the treatment cause. In terms of testing clinical treatments, practical significance optimally yields quantified information about the importance of a finding, using metrics such as effect size, number needed to treat (NNT), and preventive fraction ...
The question of whether results from a particular study generalize to other people, places or times arises only when one follows an inductivist research strategy. If the goal of a study is to deductively test a theory, one is only concerned with factors which might undermine the rigor of the study, i.e. threats to internal validity. In other ...
An event study is a statistical method to assess the impact of an event (also referred to as a "treatment"). [1] Early prominent uses of event studies occurred in the field of finance. [1] For example, the announcement of a merger between two business entities can be analyzed to see whether investors believe the merger will create or destroy value.
The p-value is widely used in statistical hypothesis testing, specifically in null hypothesis significance testing. In this method, before conducting the study, one first chooses a model (the null hypothesis) and the alpha level α (most commonly 0.05).
Comparison of the rule of three to the exact binomial one-sided confidence interval with no positive samples. In statistical analysis, the rule of three states that if a certain event did not occur in a sample with n subjects, the interval from 0 to 3/ n is a 95% confidence interval for the rate of occurrences in the population.
Hazard ratios do not reflect a time unit of the study. The difference between hazard-based and time-based measures is akin to the difference between the odds of winning a race and the margin of victory. [3] When a study reports one hazard ratio per time period, it is assumed that difference between groups was proportional.
The study of the environment can be considered to offer unique chances for the development and exercise of the general cognitive skills that Piaget's work has made educators aware of. Environmental studies are increasingly being viewed as a long-term preparation for higher environmental studies such as Sociology, Archaeology, or Historical ...
An example of a cancer study powered for a combined endpoint is disease-free survival; trial participants experiencing either death or discovery of any recurrence would constitute the endpoint. Overall Treatment Utility is an example of a multidimensional composite endpoint in cancer clinical trials.