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Oncogenesis is a peer-reviewed open access medical journal covering the molecular biology of cancer. It was established in 2012 by Douglas R. Green as a sister journal to Oncogene, of which Green was then editor-in-chief. [1] New articles are published exclusively online by Nature Publishing Group on a weekly basis. [2]
Oncogene is a peer-reviewed scientific journal published under the Springer Nature addressing cancer cell genetics and the structure and function of oncogenes. The journal has editorial office in London, England. The journal was established in 1987. [1] An open access online-only sister journal, Oncogenesis, was established in 2012 by Douglas R ...
Carcinogenesis, also called oncogenesis or tumorigenesis, is the formation of a cancer, whereby normal cells are transformed into cancer cells. The process is characterized by changes at the cellular, genetic, and epigenetic levels and abnormal cell division. Cell division is a physiological process that occurs in almost all tissues and under a ...
Oncogenomics. Oncogenomics is a sub-field of genomics that characterizes cancer -associated genes. It focuses on genomic, epigenomic and transcript alterations in cancer. Cancer is a genetic disease caused by accumulation of DNA mutations and epigenetic alterations leading to unrestrained cell proliferation and neoplasm formation.
An oncogene is a gene that has the potential to cause cancer. [1] In tumor cells, these genes are often mutated, or expressed at high levels. [2] Most normal cells undergo a preprogrammed rapid cell death (apoptosis) if critical functions are altered and then malfunction.
Tumor suppressor gene. The cell cycle. Many tumor suppressors work to regulate the cycle at specific checkpoints in order to prevent damaged cells from replicating. A tumor suppressor gene (TSG), or anti-oncogene, is a gene that regulates a cell during cell division and replication. [1] If the cell grows uncontrollably, it will result in cancer.
Oncometabolism is the field of study that focuses on the metabolic changes that occur in cells that make up the tumor microenvironment (TME) and accompany oncogenesis and tumor progression toward a neoplastic state. [1] Cells with increased growth and survivability differ from non-tumorigenic cells in terms of metabolism. [2]
Gene expression profiling is a technique used in molecular biology to query the expression of thousands of genes simultaneously. In the context of cancer, gene expression profiling has been used to more accurately classify tumors. The information derived from gene expression profiling often helps in predicting the patient's clinical outcome.