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Opioid-induced hyperalgesia (OIH) or opioid-induced abnormal pain sensitivity, also called paradoxical hyperalgesia, is an uncommon condition of generalized pain caused by the long-term use of high dosages of opioids [1] such as morphine, [2] oxycodone, [3] and methadone. [4][5] OIH is not necessarily confined to the original affected site. [6]
Hyperalgesia. Hyperalgesia (/ ˌhaɪpərælˈdʒiːziə / or /- siə /; hyper from Greek ὑπέρ (huper) 'over' + -algesia from Greek ἄλγος (algos) 'pain') is an abnormally increased sensitivity to pain, which may be caused by damage to nociceptors or peripheral nerves and can cause hypersensitivity to stimulus.
Fentanyl is a highly potent synthetic piperidine opioid primarily used as an analgesic. It is 20 to 40 times more potent than heroin and 100 times more potent than morphine; [9] its primary clinical utility is in pain management for cancer patients and those recovering from painful surgeries. [10][11] Fentanyl is also used as a sedative. [12]
4.1%-12.4% (12-month prevalence, US adults) [ 1 ] Neuropathic pain is pain caused by a lesion or disease of the somatosensory nervous system. [ 2 ][ 3 ] Neuropathic pain may be associated with abnormal sensations called dysesthesia or pain from normally non-painful stimuli (allodynia). It may have continuous and/or episodic (paroxysmal) components.
The heroin and opioid abuse epidemic is hitting America hard with heroin use more than doubling in the past decade among young adults, according to the CDC. While the dire statistics tell the ...
Opioid use disorder (OUD) is a substance use disorder characterized by cravings for opioids, continued use despite physical and/or psychological deterioration, increased tolerance with use, and withdrawal symptoms after discontinuing opioids. [ 12 ] Opioid withdrawal symptoms include nausea, muscle aches, diarrhea, trouble sleeping, agitation ...
Long-term opioid use can cause opioid-induced hyperalgesia, which is a condition in which the patient has increased sensitivity to pain. [95] All of the opioids can cause side effects. [64] Common adverse reactions in patients taking opioids for pain relief include nausea and vomiting, drowsiness, itching, dry mouth, dizziness, and constipation ...
Chronic pain or chronic pain syndrome is a type of pain that is also known by other titles such as gradual burning pain, electrical pain, throbbing pain, and nauseating pain. This type of pain is sometimes confused with acute pain [a] and can last from three months to several years; various diagnostic manuals such as DSM-5 and ICD-11 have ...