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A depsipeptide is a peptide with one or more ester groups instead of amide groups. Depsipeptides are found in natural products and have various biological activities, such as iron transport, anti-cancer and antibacterial effects.
Barth syndrome is a rare X-linked genetic disorder that affects multiple body systems, including cardiomyopathy, neutropenia, and 3-methylglutaconic aciduria. It is caused by mutations in the tafazzin gene, which regulates phospholipid metabolism and mitochondrial function.
Learn about pediatric early warning signs (PEWS), clinical manifestations that indicate rapid deterioration in pediatric patients. Find out the history, purpose, and types of PEWS systems, and how they are used to improve patient care and outcomes.
Mitochondrial DNA depletion syndrome (MDS or MDDS), also known as Alper's disease, is a group of rare inherited disorders that affect mitochondrial DNA in muscle, liver, or brain tissues. Symptoms vary depending on the type of MDS and can include muscle weakness, liver failure, seizures, developmental delay, and blindness.
Cyclothymia (/ ˌ s aɪ k l ə ˈ θ aɪ m i ə /, siy-kluh-THIY-mee-uh), also known as cyclothymic disorder, psychothemia / psychothymia, [5] bipolar III, [6] affective personality disorder [7] and cyclothymic personality disorder, [8] is a mental and behavioural disorder [9] that involves numerous periods of symptoms of depression and periods of symptoms of elevated mood. [3]
Chvostek sign is a clinical sign of low blood calcium level that causes facial muscle twitching when tapped in front of the ear. It is not a reliable sign of tetany and may be caused by other factors such as magnesium deficiency or respiratory alkalosis.
Acyldepsipeptide antibiotics (ADEPs) are a class of potential antibiotics that activate the bacterial protease ClpP and cause uncontrolled protein degradation. They are of interest for combating antibiotic resistance, but also have some limitations and possible resistance mechanisms.
The biosynthesis of depsipeptide Didemnin is governed by a hybrid non-ribosomal peptide synthetase-polyketide synthetase (NRPS-PKS) pathway. The didemnin mega-synthetase consists of 10 proteins, of which 8 NRPS and 2 PKS, covering 13 modules in total.