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Dipyridamole (trademarked as Persantine and others) is an antiplatelet drug of the nucleoside transport inhibitor and PDE3 inhibitor class that inhibits blood clot formation when given chronically and causes blood vessel dilation when given at high doses over a short time.
Thallium was originally used as rat poison, but was discontinued due to the exposure risk. Among the distinctive effects of thallium poisoning are peripheral nerve damage (victims may experience a sensation of "walking on hot coals") and hair loss (which led to its initial use as a depilatory before its
A cardiac stress test is a cardiological examination that evaluates the cardiovascular system's response to external stress within a controlled clinical setting. This stress response can be induced through physical exercise (usually a treadmill) or intravenous pharmacological stimulation of heart rate. [1]
Technetium (99m Tc) sestamibi (commonly sestamibi; USP: technetium Tc 99m sestamibi; trade name Cardiolite) is a pharmaceutical agent used in nuclear medicine imaging.The drug is a coordination complex consisting of the radioisotope technetium-99m bound to six (sesta=6) methoxyisobutylisonitrile (MIBI) ligands.
A thallium stress test is a form of scintigraphy, where the amount of thallium-201 detected in cardiac tissues correlates with tissue blood supply. Viable cardiac cells have normal Na + /K + ion exchange pumps. Thallium binds the K + pumps and is transported into the cells. Exercise or dipyridamole induces widening (vasodilation) of normal ...
The radioisotope thallium-201 (as the soluble chloride TlCl) is used in small amounts as an agent in a nuclear medicine scan, during one type of nuclear cardiac stress test. Soluble thallium salts (many of which are nearly tasteless) are highly toxic and they were historically used in rat poisons and insecticides. Because of their nonselective ...
[1] [2] For thallium it may be used in addition to gastric lavage, activated charcoal, forced diuresis, and hemodialysis. [3] [4] It is given by mouth or nasogastric tube. [2] [4] Prussian blue is also used in the urine to test for G6PD deficiency. [5] Side effects may include constipation, low blood potassium, and stools that are dark.
Dipyridamole is thus a pharmacological success diagnostically, but a therapeutic failure because of the coronary steal phenomenon. [ 4 ] Coronary steal is also the mechanism in most drug-based cardiac stress tests ; When a patient is incapable of doing physical activity they are given a vasodilator that produces a "cardiac steal syndrome" as a ...