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In humans, testosterone plays a key role in the development of male reproductive tissues such as testicles and prostate, as well as promoting secondary sexual characteristics such as increased muscle and bone mass, and the growth of body hair. It is associated with increased aggression, sex drive, dominance, courtship display, and a wide range ...
However, much later, in 2010s, [2] the role in human health of 11-oxygenated androgens was established, namely, of 11-ketotestosterone (11KT) and 11-ketodihydrotestosterone (11KDHT), that both bind and activate the human androgen receptor with affinities, potencies, and efficacies that are similar to that of testosterone (T) and DHT ...
Leuprorelin, also known as leuprolide, is a manufactured version of a hormone used to treat prostate cancer, breast cancer, endometriosis, uterine fibroids, for early puberty, or as part of transgender hormone therapy. [10][11] It is given by injection into a muscle or under the skin. [10]
In 2022, the Journal of Sex Research published a study of 26,542 men and 33,534 women that had entered same-sex unions in the Netherlands as compared with 4,607,785 men and 4,405,635 women that found robust evidence of a fraternal birth order effect on both male and female homosexuality and no support for a female fecundity effect, but the ...
In addition, the dissociation rate of DHT from the AR is 5-fold slower than that of testosterone. [49] The EC 50 of DHT for activation of the AR is 0.13 nM, which is about 5-fold stronger than that of testosterone (EC 50 = 0.66 nM). [50] In bioassays, DHT has been found to be 2.5- to 10-fold more potent than testosterone. [47]
Vosilasarm has been assessed in clinical trials in women with breast cancer at doses ranging from 50 to 150 mg/day, with the maximum safe and tolerated dose being 100 mg/day. [ 10 ] [ 3 ] [ 2 ] The drug sold via black-market Internet suppliers and used non-medically has been reported to be taken at doses of 5 to 30 mg/day, with unknown adverse ...
The human sex ratio is the ratio of males to females in a population in the context of anthropology and demography. In humans, the natural sex ratio at birth is slightly biased towards the male sex. It is estimated to be about 1.05 [1] or 1.06 [2] or within a narrow range from 1.03 to 1.06 [3] males per female.
The Women's Health Initiative (WHI) is an ongoing study of over 27,000 women that began in 1991, with the most recent analyses suggesting that, when initiated within 10 years of menopause, HRT reduces all-cause mortality and risks of coronary disease, osteoporosis, and dementia; after 10 years the beneficial effects on mortality and coronary ...