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Body fat redistribution (BFR) syndrome, sometimes called fat derangement, is a medical condition characterized by fat loss (or occasionally fat gain), often in the cheeks or face. BFR most often occurs in HIV / AIDS patients undergoing antiretroviral therapy.
HIV-associated lipodystrophy commonly presents with fat loss in face, buttocks, arms and legs. [citation needed] There is also fat accumulation in various body parts. Patients often present with "buffalo hump"-like fat deposits in their upper backs. Breast size of patients (both male and female) tends to increase.
Some of the most well known are antiviral drugs widely used to treat HIV/AIDS, hepatitis C and COVID-19. These protease inhibitors prevent viral replication by selectively binding to viral proteases (e.g. HIV-1 protease ) and blocking proteolytic cleavage of protein precursors that are necessary for the production of infectious viral particles .
Indinavir (IDV; trade name Crixivan, made by Merck) is a protease inhibitor used as a component of highly active antiretroviral therapy to treat HIV/AIDS.It is soluble white powder administered orally in combination with other antiviral drugs.
The nutritional needs of people with HIV/AIDS are also greater due to their immune system fighting off opportunistic infections that do not normally cause disease in people with healthy immune systems. [3] Medication along with proper nutrition is a major component of maintaining good health and quality of life for people living with HIV/AIDS.
It works by inhibiting the enzyme reverse transcriptase that HIV uses to make DNA and therefore decreases replication of the virus. [6] Zidovudine was first described in 1964. [7] It was resynthesized from a public-domain formula by Burroughs Wellcome. [8] It was approved in the United States in 1987 and was the first treatment for HIV.
Anti-obesity medication or weight loss medications are pharmacological agents that reduce or control excess body fat. These medications alter one of the fundamental processes of the human body , weight regulation, by: reducing appetite and consequently energy intake , increasing energy expenditure , redirecting nutrients from adipose to lean ...
HIV-1 protease is one of the best known aspartic proteases, and an attractive target for the treatment of AIDS. [9] After the discovery of HIV protease it only took 10 years for its first inhibitor to reach the market. [10] The first reports of highly selective antagonists against the HIV protease were revealed in 1987.