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The most commonly reported side effects due to use of tenofovir disoproxil were dizziness, nausea, and diarrhea. [13] Other adverse effects include depression, sleep disturbances, headache, itching, rash, and fever. The US boxed warning cautions potential onset of lactic acidosis or liver damage due to use of tenofovir disoproxil. [14]
Serious side effects may include high blood lactate levels and enlargement of the liver. [7] Use of this medication during pregnancy does not appear to harm the fetus, but this has not been well studied. [1] Emtricitabine/tenofovir was approved for medical use in the United States in 2004. [5]
It is a combination of dolutegravir, lamivudine, and tenofovir disoproxil. [1] As of 2019, it is listed by the World Health Organization (WHO) as the first line treatment for adults, with tenofovir/lamivudine/efavirenz as an alternative. [2] It is taken by mouth. [3] Side effects may include trouble sleeping, weight gain, and rash.
meloxicam – nonsteroidal anti-inflammatory drug (NSAID) metacam – used to reduce inflammation and pain; methimazole – used in treatment of hyperthyroidism; methocarbamol - muscle relaxant used to reduce muscle spasms associated with inflammation, injury, intervertebral disc disease, and certain toxicities
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More severe side effects are hallucinations, sleeplessness and depression. [12] Recommended dosage for efavirenz/emtricitabine/tenofovir is one tablet at or before bedtime. Side effects can be reduced if it is taken on an empty stomach. People with kidney or liver problems can take one tablet by mouth once a day.
Bictegravir should not be used with dofetilide and rifampin. [16] Use of dofetilide with bictegravir increases the concentration of dofetilide, which can lead to life-threatening events. [16] Concomitant use of bictegravir and rifampin causes significant interactions because of an effect rifampin has on bictegravir. [16]
These changes minimize interactions between drugs, lower clearance, and increase solubility. Bictegravir was found to be less drug resistant than other drugs in the same class. [16] Emtricitabine (FTC) is a nucleoside reverse transcriptase inhibitor (NRTI) that is a synthetic fluoro derivative of thiacytidine. Within the cell, emtricitabine ...
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