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A prokinetic agent (also prokineticin, gastroprokinetic agent, gastrokinetic agent or propulsive) is a type of drug which enhances gastrointestinal motility by increasing the frequency or strength of contractions, but without disrupting their rhythm. [1]
Anticholinergics, magnesium, or sodium (to raise blood pressure) supplements; Anticonvulsants have eliminated all symptoms in some Roemheld syndrome sufferers; Lorazepam, Oxcarbazepine increase GI motility, reduce vagus "noise" (sodium channel blocking believed to contribute to positive effects)
Decreasing intestinal motility prolongs the transit time of food content through the digestive tract, which allows for more fluid absorption; thereby alleviating diarrhea symptoms and improving stool consistency and frequency. [4] Unlike other opiates, loperamide does not cross the blood brain barrier, so there is minimal risk for abuse. [5]
Abnormal motility Studies have shown altered muscle contractility and tone, bowel compliance, and transit may contribute to many of the gastrointestinal symptoms of FGID which may include diarrhea, constipation, and vomiting. [20] Visceral hypersensitivity In FGID there is poor association of pain with GI motility in many functional GI disorders.
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If intestinal activity is high, amphetamine may reduce gastrointestinal motility (the rate at which content moves through the digestive system); [79] however, amphetamine may increase motility when the smooth muscle of the tract is relaxed. [79] Amphetamine also has a slight analgesic effect and can enhance the pain relieving effects of opioids ...
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