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Gastric signet ring cell carcinoma histopathology, PAS stain Esophageal candidiasis, PAS stain Liver in glycogen storage disease, PAS stain. PAS staining is mainly used for staining structures containing a high proportion of carbohydrate macromolecules (glycogen, glycoprotein, proteoglycans), typically found in e.g. connective tissues, mucus, the glycocalyx, and basal laminae.
PAS diastase stain is also used to identify alpha-1 antitrypsin globules in hepatocytes, which is a characteristic finding of alpha-1 antitrypsin deficiency. [2] PAS diastase stain is also used in diagnosing Whipple’s disease , as the foamy macrophages that infiltrate the lamina propria of the small intestine in this disease possess PAS ...
The PAS with diastase stain shows the diastase-resistant pink globules that are characteristic of this disease. See also: Alpha-1 antitrypsin A1AT is a glycoprotein mainly produced in the liver by hepatocytes, [ 9 ] and, in some quantity, by enterocytes , monocytes , and macrophages . [ 12 ]
[13] Periodic acid-Schiff is a histology special stain used to mark carbohydrates (glycogen, glycoprotein, proteoglycans). PAS is commonly used on liver tissue where glycogen deposits are made which is done in efforts to distinguish different types of glycogen storage diseases.
Joseph Forde Anthony McManus, (July 13, 1911 – March 4, 1980) was a Canadian pathologist who is best known for his formulation of one of the most frequently used stains in histopathology; the McManus Periodic acid-Schiff stain. Joe McManus was a pioneer in the field of Histochemistry during its period of expanding growth and application in ...
Jones' stain, also Jones stain, is a methenamine silver–periodic acid–Schiff stain used in pathology. [1] It is also referred to as methenamine PAS which is commonly abbreviated MPAS . It stains for basement membrane and is widely used in the investigation of medical kidney diseases .
Micrograph showing casts in a kidney biopsy using PAS stain: Hyaline casts are PAS-positive (dark pink/red, right of image). Myelomatous casts are PAS-negative (pale pink, left of image) Urinary casts are microscopic cylindrical structures produced by the kidney and present in the urine in certain disease states.
Clinically, VM is diagnosed through immunohistochemistry (IHC) and Periodic acid-Schiff stain (PAS) of patient tumor biopsy. IHC staining identifies the expression of common biomarkers of endothelial cells such as CD31, while PAS staining marks the extracellular matrix for glycoproteins, laminin, proteoglycans, heparin sulfate and collagens ...