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Linaclotide, like the endogenous guanylin and uroguanylin it mimics, is an agonist that activates the cell surface receptor of guanylate cyclase 2C (GC-C). [12] [4] [14] The medication binds to the surface of the intestinal epithelial cells. [4] Linaclotide is minimally absorbed and it is undetectable in the systemic circulation at therapeutic ...
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14917 Ensembl ENSG00000070019 ENSMUSG00000042638 UniProt P25092 Q3UWA6 RefSeq (mRNA) NM_004963 NM_001127318 NM_145067 RefSeq (protein) NP_004954 NP_001120790 NP_659504 Location (UCSC) Chr 12: 14.61 – 14.7 Mb Chr 6: 136.67 – 136.76 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse Guanylate cyclase 2C, also known as guanylyl cyclase C (GC-C), intestinal guanylate cyclase, guanylate ...
Linaclotide Receives Positive CHMP Opinion for the Treatment of IBS-C -Linaclotide is a first-in-class therapeutic option for the symptomatic treatment of moderate to severe irritable bowel ...
The following other wikis use this file: Usage on ar.wikipedia.org ليناكلوتيد; Usage on es.wikipedia.org Linaclotida; Usage on fa.wikipedia.org
This is an accepted version of this page This is the latest accepted revision, reviewed on 16 February 2025. List of organ systems in the human body Part of a series of lists about Human anatomy General Features Regions Variations Movements Systems Structures Arteries Bones Eponymous Foramina Glands endocrine exocrine Lymphatic vessels Nerves Organs Systems Veins Muscles Abductors Adductors ...
The human digestive system consists of the gastrointestinal tract plus the accessory organs of digestion (the tongue, salivary glands, pancreas, liver, and gallbladder). Digestion involves the breakdown of food into smaller and smaller components, until they can be absorbed and assimilated into the body.
The clitoris is the only organ in the human body that exists exclusively for pleasure. Those in the medical community had no reason to assume they were wrong. The anatomical “maps” that anchored their education must have seemed as sturdy and steadfast as Mercator’s, with every organ plotted and every muscle annotated.