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Linaclotide, like the endogenous guanylin and uroguanylin it mimics, is an agonist that activates the cell surface receptor of guanylate cyclase 2C (GC-C). [12] [4] [14] The medication binds to the surface of the intestinal epithelial cells. [4] Linaclotide is minimally absorbed and it is undetectable in the systemic circulation at therapeutic ...
Linaclotide Receives Positive CHMP Opinion for the Treatment of IBS-C -Linaclotide is a first-in-class therapeutic option for the symptomatic treatment of moderate to severe irritable bowel ...
The wakefulness-promoting agent modafinil and its analogues (e.g., adrafinil, armodafinil) have been approved to treat narcolepsy and shift work sleep disorder. [6] These act as weak ( micromolar ) DRIs, [ 7 ] but this effect does not correlate with wakefulness-promoting effects, suggesting the effect is too weak to be of clinical significance.
Lipinski's rule of five, also known as Pfizer's rule of five or simply the rule of five (RO5), is a rule of thumb to evaluate druglikeness or determine if a chemical compound with a certain pharmacological or biological activity has chemical properties and physical properties that would likely make it an orally active drug in humans.
This is an accepted version of this page This is the latest accepted revision, reviewed on 16 February 2025. List of organ systems in the human body Part of a series of lists about Human anatomy General Features Regions Variations Movements Systems Structures Arteries Bones Eponymous Foramina Glands endocrine exocrine Lymphatic vessels Nerves Organs Systems Veins Muscles Abductors Adductors ...
One of the most common forms of heart failure happens when the left heart ventricle (responsible for pumping oxygen-rich blood to the rest of the body) can’t effectively do its job.
Its body text is behind a paywall. It may well be possible that that is why the wording in question has withstood the winds of time, as Joe Public can't access the main text. Many people would be unable to uncover for themselves that the wording was based on a quick (but understandable) misread, presumably of the abstract only, as it is ...
The clitoris is the only organ in the human body that exists exclusively for pleasure. Those in the medical community had no reason to assume they were wrong. The anatomical “maps” that anchored their education must have seemed as sturdy and steadfast as Mercator’s, with every organ plotted and every muscle annotated.
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