Search results
Results from the WOW.Com Content Network
Sirtuin 1, also known as NAD-dependent deacetylase sirtuin-1, is a protein that in humans is encoded by the SIRT1 gene. [5] [6] [7]SIRT1 stands for sirtuin (silent mating type information regulation 2 homolog) 1 (S. cerevisiae), referring to the fact that its sirtuin homolog (biological equivalent across species) in yeast (Saccharomyces cerevisiae) is Sir2.
[2] [3] They are ancient in animal evolution and appear to possess a highly conserved structure throughout all kingdoms of life. [2] Chemically, sirtuins are a class of proteins that possess either mono- ADP-ribosyltransferase or deacylase activity, including deacetylase, desuccinylase , demalonylase , demyristoylase and depalmitoylase activity.
In September 2003, Howitz and Sinclair et al. published a highly cited paper reporting that polyphenols such as resveratrol [2] activate human SIRT1 and extend the lifespan of budding yeast (Howitz et al., Nature, 2003).
UniProt Archive (UniParc) is a comprehensive and non-redundant database, which contains all the protein sequences from the main, publicly available protein sequence databases. [17] Proteins may exist in several different source databases, and in multiple copies in the same database.
Since the discovery of SRT1720, the claim that this compound is a SIRT1 activator has been questioned [4] [5] [6] and further defended. [ 7 ] [ 8 ] Although SRT1720 is not currently undergoing clinical development, a related compound, SRT2104 , reached Phase II human trials for metabolic diseases.
NAD-dependent deacetylase sirtuin 2 is an enzyme that in humans is encoded by the SIRT2 gene. [ 5 ] [ 6 ] [ 7 ] SIRT2 is an NAD+ (nicotinamide adenine dinucleotide)-dependent deacetylase. Studies of this protein have often been divergent, highlighting the dependence of pleiotropic effects of SIRT2 on cellular context.
With 1,838 yards, the seven-year veteran has to average 133.5 yards in those final two games to seize the all-time mark. Barkley has topped that number in six of his 15 games this season.
The inaugural production was directed by Jeremy Herrin and staged in the Dorfman Theatre at the National Theatre in London in 2015. The play was widely praised by critics for its depiction of addiction, and Denise Gough, in the central role, won the Critics Circle Theatre Award for Best Actress.