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Drug tolerance is indicative of drug use but is not necessarily associated with drug dependence or addiction. [4] The process of tolerance development is reversible (e.g., through a drug holiday [5]) and can involve both physiological factors and psychological factors. [6] One may also develop drug tolerance to side effects, [7] in which case ...
This dynamic explains tolerance, which is the increase in the amount of drug/substance that is needed to overcome the opponent process that is increasing in strength. This also explains withdrawal syndrome, which occurs by the negative, drug-opposite effects remaining after the initial, pleasurable process dies out. [10]
addiction – a biopsychosocial disorder characterized by persistent use of drugs (including alcohol) despite substantial harm and adverse consequences addictive drug – psychoactive substances that with repeated use are associated with significantly higher rates of substance use disorders, due in large part to the drug's effect on brain ...
Chemistry, not moral failing, accounts for the brain’s unwinding. In the laboratories that study drug addiction, researchers have found that the brain becomes conditioned by the repeated dopamine rush caused by heroin. “The brain is not designed to handle it,” said Dr. Ruben Baler, a scientist with the National Institute on Drug Abuse.
First, desensitization may be equivalent to drug tolerance and refers to subjects' reactions (positive or negative) to a drug reducing following its repeated use. This is a macroscopic, organism-level effect and differs from the second meaning of desensitization, which refers to a biochemical effect where individual receptors become less ...
Drug intolerance or drug sensitivity refers to an inability to tolerate the adverse effects of a medication, generally at therapeutic or subtherapeutic doses. Conversely, a patient is said to be "tolerating" a drug when they can tolerate its adverse effects.
Reverse tolerance or drug sensitization is a pharmacological phenomenon describing subjects' increased reaction (positive or negative) to a drug following its repeated use. [4] Not all drugs are subject to reverse tolerance. This is the opposite of drug tolerance, in which the effect or the subject's reaction decreases following its repeated ...
Addiction is a fairly broad term; it is most often associated with substance use disorders, but it can also be extended to cover a number of other compulsive behaviors, including sex, internet, television, gambling, food, and shopping. Within these categories of addiction a common diagnostic scale involves tolerance, withdrawal, and cravings. [1]