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Infants and young children with Kindler syndrome have a tendency to blister with minor trauma and are prone to sunburns. As individuals with Kindler syndrome age, they tend to have fewer problems with blistering and photosensitivity. However, pigment changes and thinning of the skin become more prominent. [4]
Medetomidine is a veterinary anesthetic drug with potent sedative effects and emerging illicit drug adulterant. [ 1 ] It is a racemic mixture of two stereoisomers , levomedetomidine and dexmedetomidine , the latter being the isomer with the pharmacologic effect as an alpha 2- adrenergic agonist .
The hands and feet usually are the first to show signs of the disease but the disease can advance to other parts of the body. Signs of the disease include thickening of the skin, on hands and soles of feet, which can turn red in color. [6] There currently is no cure and treatment is limited, but Acitretin can be used in severe cases. [7]
Hunter Steinitz (born October 17, 1994) as of June 2010 was 16 and one of only twelve Americans living with the disease, and was profiled on National Geographic's "Extraordinary Humans: Skin" special. [37] Mui Thomas (born in 1992 in Hong Kong) was 24 as of 2016 and qualified as the first rugby referee with harlequin ichthyosis. [38]
Dukes' disease, named after Clement Dukes (1845–1925), [1] [2] also known as fourth disease, [3] Filatov-Dukes' disease (after Nil Filatov), [4] Staphylococcal Scalded Skin Syndrome (SSSS), [5] or Ritter's disease [6] is an exanthem (rash-causing) illness primarily affecting children and historically described as a distinct bacterial infection, though its existence as a separate disease ...
Together with Stevens–Johnson syndrome (SJS) it forms a spectrum of disease, with TEN being more severe. [2] Early symptoms include fever and flu-like symptoms. [2] A few days later the skin begins to blister and peel forming painful raw areas. [2] Mucous membranes, such as the mouth, are also typically involved. [2]
Epidermolysis bullosa dystrophica or dystrophic EB (DEB) is an inherited disease affecting the skin and other organs. [1] [2] "Butterfly child" is the colloquial name for children born with the disease, as their skin is seen to be as delicate and fragile as the wings of a butterfly. [3]
Identification of the physical symptoms is important to distinguish this disease from Papillon-Lefevre Syndrome. [6] Because of this, Haim-Munk syndrome is often diagnosed at an early age. [9] In many cases diagnosis of Haim–Munk syndrome may be difficult in small children, as many symptoms can be confused with other skin abnormalities.