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Bradykinin (BK) (from Greek brady-'slow' + -kinin, kīn(eîn) 'to move') is a peptide that promotes inflammation.It causes arterioles to dilate (enlarge) via the release of prostacyclin, nitric oxide, and endothelium-derived hyperpolarizing factor and makes veins constrict, via prostaglandin F2, thereby leading to leakage into capillary beds, due to the increased pressure in the capillaries.
Bradycardia, also called bradyarrhythmia, is a resting heart rate under 60 beats per minute (BPM). [1] While bradycardia can result from various pathologic processes, it is commonly a physiologic response to cardiovascular conditioning or due to asymptomatic type 1 atrioventricular block.
An exercise mimetic is a drug that mimics some of the biological effects of physical exercise. Exercise is known to have an effect in preventing, treating, or ameliorating the effects of a variety of serious illnesses, including cancer , type 2 diabetes , cardiovascular disease , and psychiatric and neurological diseases such as Alzheimer's ...
A wealth of recent research, including a new study published this month in the Journal of Alzheimer's Disease, suggests that any type of exercise that raises your heart rate and gets you moving ...
Exercise mimetics are a proposed class of drugs that aim to do exactly what the name suggests: mimic the health benefits of exercise. SLU-PP-332 and the new compounds fall into this category.
Athletic heart syndrome (AHS) is a non-pathological condition commonly seen in sports medicine in which the human heart is enlarged, and the resting heart rate is lower than normal. The athlete's heart is associated with physiological cardiac remodeling as a consequence of repetitive cardiac loading. [ 3 ]
A cardiac stimulant is a drug which acts as a stimulant of the heart – e.g., via positive chronotropic action (increased heart rate) and/or inotropic action (increased myocardial contractility). They increase cardiac output (the amount of blood pumped by the heart over time).
This leads the increase in heart rate to compensate for the reduced cardiac output during exercise. [6] This inefficient cardiac output leads to a decrease in the maximum amount of oxygen used by the body – VO 2Max. [8] This affects exercise performance by reducing the amount of oxygen that is delivered to the muscles during exercise. [8]